Biologic and pharmacologic regulation of mammalian glutathione synthesis.
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Cites background from "Biologic and pharmacologic regulati..."
...A recent forum on glutathione in Free Radical Biology and Medicineprovides more information on GSH and its cellular functions [59], regulation of GSH synthesis [60], gene expression and thiol redox state [52], BCL-2 and GSH [61], glutathione peroxidases [62], thiol-dependent hydroperoxide metabolism in parasites [63], and export pumps for GSH S-conjugates [64]....
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Cites background from "Biologic and pharmacologic regulati..."
...Procysteine drugs such as N-acetylcysteine have been used clinically to stimulate cystineglutamate exchange and restore glutathione following acetaminophen overdose (107)....
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"Biologic and pharmacologic regulati..." refers background in this paper
...It is known that oxidant stress induces NF-kB binding activity in addition to AP-1 activity [11,12], and several studies have implicated NF-kB in the upregulation of g-GCSH expression in response to inflammatory cytokines (e....
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...quences: (i) the thiol redox status of the cell will shift, activating certain oxidant response transcriptional elements [11,12], and (ii) GSSG may be preferentially secreted from the cell [13]....
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1,108 citations
"Biologic and pharmacologic regulati..." refers background in this paper
...Although GSH reacts spontaneously with some electrophiles [14], most such reactions require catalysis by an extended family of enzymes known as GSH S-transferases [15]....
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...endogenously by the cytochrome P450 system [14–16]....
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930 citations