Biomarkers in sepsis.
Citations
662 citations
Cites background from "Biomarkers in sepsis."
...A kinetic study of high mobility group box 1 demonstrated that it remained persistently elevated in the plasma compared with cytokines such as IL-6, IL-8, and TNF, emphasizing this biomarker’s high clinical relevance (90, 92, 116)....
[...]
...CRP does not play a major role in diagnosis, and prediction of outcome in sepsis due to its low specificity (90, 96)....
[...]
...The utility of a biomarker for the diagnosis of sepsis should be judged on its ability to shorten the time necessary to make a diagnosis, improve discrimination between infectious and noninfectious causes of inflammation, enhance differentiation of viral from bacterial infections, and assess appropriate control of the infection (90)....
[...]
...Biomarker-based immunomonitoring offers a versatile approach for various disease and prevention scenarios (90)....
[...]
...timely information beyond the data generated during routine physiologic evaluation, thereby allowing the prospect of successful intervention before the therapeutic window permanently closes (90)....
[...]
429 citations
Cites background from "Biomarkers in sepsis."
...TNF-treated patients at higher levels of IL-6 monoclonal antibody (170)....
[...]
...The potential of biomarkers in the field of sepsis was first addressed systematically in the context of a colloquium convened by the International Sepsis Forum in 2005 (170)....
[...]
...size physiologic changes in vital parameters that are common to a number of disparate processes,” and that “biomarkers promise to transform sepsis from a physiologic syndrome to a group of distinct biochemical disorders” (170)....
[...]
...Furthermore, it is important to note that an adequate evaluation of clinical utility is possible only if the assays that are used in this context for biomarker measurement provide reliable and reproducible results (170)....
[...]
391 citations
Cites background from "Biomarkers in sepsis."
...The use of biomarkers may be useful in the detection of infection and in the management of the septic patient; despite the fact that more than 100molecules have been evaluated in sepsis [6], an ideal biomarker, that is to say a molecule which, at the same time, allows early diagnosis, risk stratification, monitoring of clinical response to therapy, and prediction of outcome [7], is still missing....
[...]
252 citations
Cites background from "Biomarkers in sepsis."
...Discussion The development of a reliable, sensitive, and specific scoring system can effectively facilitate comparison of disease outcomes and therapeutic regimens [5,7,21] across multiple models of sepsis, and improve the clinical relevance of novel diagnostic biomarkers [21]....
[...]
240 citations
Cites background from "Biomarkers in sepsis."
...Ideally, sepsis studies should use specific biomarkers to help patient enrollment and weigh treatment efficacy in realistic conditions (155)....
[...]
References
2,698 citations
1,797 citations
1,290 citations
1,123 citations
1,086 citations