Biomarkers of Epithelial-Mesenchymal Transition in Squamous Cell Carcinoma
Citations
376 citations
Cites background from "Biomarkers of Epithelial-Mesenchyma..."
...With regard to the former, a number of studies have linked disturbed shear stress and endothelial production of fibronectin (17, 22), a well-established marker of epithelial-to-mesenchymal transition (23, 24)....
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References
4,161 citations
"Biomarkers of Epithelial-Mesenchyma..." refers background in this paper
...Since patients with HNSCC often present with late-stage tumors, the five-year survival rate is only 50%, which is poorer than that for breast cancer or melanoma (Siegel et al., 2011)....
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2,090 citations
"Biomarkers of Epithelial-Mesenchyma..." refers background in this paper
...Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in the world (Leemans et al., 2011)....
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...INTRODUCTION Head and neck squamous cell carcinoma (HNSCC) is the sixth most com-mon cancer in the world (Leemans et al., 2011)....
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2,016 citations
"Biomarkers of Epithelial-Mesenchyma..." refers background in this paper
...Expression of zona-occludens 1 (ZO-1) occurs in all 3 types of EMT (Zeisberg and Neilson, 2009)....
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...Fibronectin is a glycoprotein scaffold for fibrillar ECM (Zeisberg and Neilson, 2009)....
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...There is increased expression of collagen I (α1) and collagen III (α1) in type 1 and 3 EMT, while collagen IV (α1) is down-regulated in all 3 types of EMT (Zeisberg and Neilson, 2009)....
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...Zinc finger E-box binding homeobox 1 (ZEB1) is an E-cadherin transcriptional repressor that is down-regulated by miR-200 microRNAs in cancer cells that display an EMT phenotype (Zeisberg and Neilson, 2009)....
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...Osteoblast cadherin (OB-cadherin) is a definitive marker for activated fibroblasts (Zeisberg and Neilson, 2009)....
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744 citations
"Biomarkers of Epithelial-Mesenchyma..." refers background in this paper
...While migration of normal cells is strictly controlled by limited proteolysis of the ECM, in cancer, proteolytic remodeling of the ECM facilitates invasion (Egeblad et al., 2010)....
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665 citations
"Biomarkers of Epithelial-Mesenchyma..." refers background in this paper
...E-cadherin is anchored to the cytoskeleton via β-catenin, a cytoplasmic plaque protein (Wheelock and Johnson, 2003)....
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