Journal ArticleDOI
Biomarkers of oxidative stress in ruminant medicine
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TLDR
The goal of this review is to discuss the advantages and shortfalls of different methodologies commonly used to measure oxidative stress and damage in ruminants and propose the development of an oxidative stress index as an approach in Ruminant and veterinary medicine.Abstract:
The study of oxidative stress is a relatively young field of research in ruminant medicine. Oxidative stress results from increased exposure to or production of oxidants, or from decreased dietary intake, de novo synthesis or increased turnover of antioxidants. The understanding of the role of oxidants and antioxidants in physiological and pathological conditions is rapidly increasing. Oxidative stress is an active field of research in veterinary medicine and has been implicated in numerous disease processes including sepsis, mastitis, acidosis, ketosis, enteritis, pneumonia, respiratory, and joint diseases. Compared to human medicine, only a limited number of conditions have been investigated in regard to the effects of oxidative stress in ruminants. Studies in cattle have been sporadic and mainly with mastitis, pneumonia, and retained placenta. More recently, studies have been focused on metabolic diseases that affect dairy cows during the peripartum period. Numerous and rapidly evolving methodologies for evaluating oxidative stress are available to researchers and clinicians, each with their own distinct advantages and disadvantages. Differences in models and methodologies make it difficult to make meaningful comparisons, even for studies that seem quite similar superficially. With this in mind, it is the goal of this review to discuss the advantages and shortfalls of different methodologies commonly used to measure oxidative stress and damage in ruminants. Clarity of understanding of the pathophysiology of oxidative stress in ruminants will allow the design of specific antioxidant therapies. Future research should focus on the establishment of a reference panel of biomarker of oxidative stress to be used in ruminant medicine. To help accelerate practical applications, we propose the development of an oxidative stress index as an approach in ruminant and veterinary medicine.read more
Citations
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Correction: Corrigendum: Gene expression differences in Longissimus muscle of Nelore steers genetically divergent for residual feed intake
Polyana C. Tizioto,Luiz Lehmann Coutinho,Priscila S. N. de Oliveira,Aline Silva Mello Cesar,Wellison Jarles da Silva Diniz,Andressa Oliveira de Lima,M. I. P. Rocha,Jared E. Decker,Robert D. Schnabel,Gerson Barreto Mourão,Rymer Ramiz Tullio,Adhemar Zerlotini,Jeremy F. Taylor,Luciana Correia de Almeida Regitano +13 more
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Oxidant/Antioxidant Balance in Animal Nutrition and Health: The Role of Protein Oxidation
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TL;DR: This review examines the role that oxidative stress, and protein oxidation in particular, plays in nutrition, metabolism, and health of farm animals.
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The importance of the oxidative status of dairy cattle in the periparturient period: revisiting antioxidant supplementation.
TL;DR: Reviewing the physiological and harmful effects of ROS production, along with the different options available for assessing the redox balance in dairy cattle and some of the key findings of different supplementation trials, could bring one step forward the on-farm application of determinations of oxidative status for establishing nutritional strategies early enough in the dry period that could improve transition cow health.
Journal ArticleDOI
Oxidative stress index (OSi) as a new tool to assess redox status in dairy cattle during the transition period.
TL;DR: Test under field conditions the use of an oxidative stress index (OSi) as a combined measurement through a ratio between pro-oxidants and antioxidants throughout the transition period in dairy farms confirmed that dairy cows undergo OS after parturition, and that antioxidant supplementation from 1 month before parturitions until the peak of lactation may be needed to reduce the risk of OS.
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The nexus between nutrient metabolism, oxidative stress and inflammation in transition cows
TL;DR: The ability to detect signs of metabolic stress early enough in the dry period to implement needed management adjustments before calving will be the key to successful monitoring and intervention programs.
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Journal ArticleDOI
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Journal ArticleDOI
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