Biomass-Based Carbon Dots: Current Development and Future Perspectives.
TL;DR: In this article, the authors highlight the advantages of these biomass-based carbon dots in terms of synthesis, properties, and applications in the biomedical field and highlight the future development of biomass derived quantum dots.
Abstract: Carbon dots have been considered as a solution to the challenges that semiconductor quantum dots have encountered because they are more biocompatible and can be synthesized from abundant and nontoxic materials such as biomass. This review will highlight the advantages of these biomass-based carbon dots in terms of synthesis, properties, and applications in the biomedical field. Furthermore, future applications especially in the biomedical field of biomass-based carbon dots as well as the challenges of semiconductor quantum dots such as biocompatibility, photobleaching, environmental challenges, toxicity, and poor solubility will be discussed in detail. Biomass-derived quantum dots, a subsection of carbon dots that are the most desirable for future research, will be focused upon including from synthesis to applications. Finally, the future development of biomass derived quantum dots in the biomedical field will be discussed and evaluated to unlock the potential for their applications.
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TL;DR: This study suggests that natural product-derived CQDs from coffee can serve as biologically safe nanozymes for anticancer therapeutics and may aid the development of nanotechnology-based immunotherapeutic.
Abstract: Carbon quantum dots (CQDs) offer huge potential due to their enzymatic properties as compared to natural enzymes. Thus, discovery of CQDs-based nanozymes with low toxicity from natural resources, especially daily food, implies a promising direction for exploring treatment strategies for human diseases. Here, we report a CQDs-based biocompatible nanozyme prepared from chlorogenic acid (ChA), a major bioactive natural product from coffee. We found that ChA CQDs exhibited obvious GSH oxidase-like activities and subsequently promoted cancer cell ferroptosis by perturbation of GPX4-catalyzed lipid repair systems. In vivo, ChA CQDs dramatically suppressed the tumor growth in HepG2-tumor-bearing mice with negligible side toxicity. Particularly, in hepatoma H22-bearing mice, ChA CQDs recruited massive tumor-infiltrating immune cells including T cells, NK cells, and macrophages, thereby converting "cold" to "hot" tumors for activating systemic antitumor immune responses. Taken together, our study suggests that natural product-derived CQDs from coffee can serve as biologically safe nanozymes for anticancer therapeutics and may aid the development of nanotechnology-based immunotherapeutic.
41 citations
TL;DR: In this article , single-atom nanozyme-mediated catalytic therapy was explored to precisely target drug-resistant GBM via the lysosomal-mediated autophagic cell death pathway.
39 citations
TL;DR: Fluorescent carbon dots grabs huge attention in analytical and bioanalytical applications due to their high selectivity towards target analyte, specificity, photostability, and quantum yield.
Abstract: Fluorescent carbon dots (CDs) grabs huge attention in analytical and bioanalytical applications due to their high selectivity towards target analyte, specificity, photostability, and quantum yield. Cost-effective and biocompatible properties of...
30 citations
TL;DR: Findings uncover that CDs have a Ca2-mobilizing property and thus can be used as a simultaneous Ca2+ signaling amplifier and ROS scavenger for crop improvement.
Abstract: Biomass-derived carbon dots (CDs) are promising nanotools for agricultural applications and function as a reactive oxygen species (ROS) scavenger to alleviate plant oxidative stress under adverse environments. Nevertheless, plants need ROS burst to fully activate Ca2+-regulated defensive signaling pathway. The underlying mechanism of CDs to improve plant environmental adaptability without ROS is largely unknown. Here, Salvia miltiorrhiza-derived CDs triggered ROS-independent Ca2+ mobilization in plant roots. Mechanistic investigation attributed this function mainly to the hydroxyl and carboxyl groups on CDs. CDs-triggered Ca2+ mobilization was found to be dependent on the production of cyclic nucleotides and cyclic nucleotide-gated ion channels. Lectin receptor kinases were verified as essential for this Ca2+ mobilization. CDs hydroponic application promoted Ca2+ signaling and plant environmental adaptability under salinity and nutrient-deficient conditions. All these findings uncover that CDs have a Ca2+-mobilizing property and thus can be used as a simultaneous Ca2+ signaling amplifier and ROS scavenger for crop improvement.
24 citations
References
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TL;DR: Aggregation greatly boosts emission efficiency of the silole, turning it from a weak luminophor into a strong emitter.
5,916 citations
TL;DR: It is reported that nanoscale carbon particles (carbon dots) upon simple surface passivation are strongly photoluminescent in both solution and the solid state.
Abstract: We report that nanoscale carbon particles (carbon dots) upon simple surface passivation are strongly photoluminescent in both solution and the solid state. The luminescence emission of the carbon dots is stable against photobleaching, and there is no blinking effect. These strongly emissive carbon dots may find applications similar to or beyond those of their widely pursued silicon counterparts.
3,817 citations
TL;DR: The progress in the research and development of CQDs is reviewed with an emphasis on their synthesis, functionalization and technical applications along with some discussion on challenges and perspectives in this exciting and promising field.
Abstract: Fluorescent carbon nanoparticles or carbon quantum dots (CQDs) are a new class of carbon nanomaterials that have emerged recently and have garnered much interest as potential competitors to conventional semiconductor quantum dots. In addition to their comparable optical properties, CQDs have the desired advantages of low toxicity, environmental friendliness low cost and simple synthetic routes. Moreover, surface passivation and functionalization of CQDs allow for the control of their physicochemical properties. Since their discovery, CQDs have found many applications in the fields of chemical sensing, biosensing, bioimaging, nanomedicine, photocatalysis and electrocatalysis. This article reviews the progress in the research and development of CQDs with an emphasis on their synthesis, functionalization and technical applications along with some discussion on challenges and perspectives in this exciting and promising field.
3,514 citations
TL;DR: Arc-synthesized single-walled carbon nanotubes have been purified through preparative electrophoresis in agarose gel and glass bead matrixes and promise to be interesting nanomaterials in their own right.
Abstract: Arc-synthesized single-walled carbon nanotubes have been purified through preparative electrophoresis in agarose gel and glass bead matrixes. Two major impurities were isolated: fluorescent carbon and short tubular carbon. Analysis of these two classes of impurities was done. The methods described may be readily extended to the separation of other water-soluble nanoparticles. The separated fluorescent carbon and short tubule carbon species promise to be interesting nanomaterials in their own right.
3,357 citations
TL;DR: In this paper, the authors describe the synthesis of ZnS-capped CdSe semiconductor nanocrystals using organometallic reagents by a two-step single-flask method X-ray photoelectron spectroscopy, transmission electron microscopy and optical absorption.
Abstract: We describe the synthesis of ZnS-capped CdSe semiconductor nanocrystals using organometallic reagents by a two-step single-flask method X-ray photoelectron spectroscopy, transmission electron microscopy and optical absorption are consistent with nanocrystals containing a core of nearly monodisperse CdSe of 27−30 A diameter with a ZnS capping 6 ± 3 A thick The ZnS capping with a higher bandgap than CdSe passivates the core crystallite removing the surface traps The nanocrystals exhibit strong and stable band-edge luminescence with a 50% quantum yield at room temperature
2,824 citations