Biomimetic electrospun nanofibrous structures for tissue engineering
TL;DR: This review provides a brief overview of current state-of-the-art research designing and using biomimetic electrospun nanofibers as scaffolds for tissue engineering.
About: This article is published in Materials Today.The article was published on 2013-06-01 and is currently open access. It has received 640 citations till now.
Citations
More filters
TL;DR: This work aims to provide a comprehensive overview of electrospun nanofibers, including the principle, methods, materials, and applications, and highlights the most relevant and recent advances related to the applications by focusing on the most representative examples.
Abstract: Electrospinning is a versatile and viable technique for generating ultrathin fibers. Remarkable progress has been made with regard to the development of electrospinning methods and engineering of electrospun nanofibers to suit or enable various applications. We aim to provide a comprehensive overview of electrospinning, including the principle, methods, materials, and applications. We begin with a brief introduction to the early history of electrospinning, followed by discussion of its principle and typical apparatus. We then discuss its renaissance over the past two decades as a powerful technology for the production of nanofibers with diversified compositions, structures, and properties. Afterward, we discuss the applications of electrospun nanofibers, including their use as "smart" mats, filtration membranes, catalytic supports, energy harvesting/conversion/storage components, and photonic and electronic devices, as well as biomedical scaffolds. We highlight the most relevant and recent advances related to the applications of electrospun nanofibers by focusing on the most representative examples. We also offer perspectives on the challenges, opportunities, and new directions for future development. At the end, we discuss approaches to the scale-up production of electrospun nanofibers and briefly discuss various types of commercial products based on electrospun nanofibers that have found widespread use in our everyday life.
2,289 citations
TL;DR: The inherently high surface to volume ratio of electrospun fibers can enhance cell attachment, drug loading, and mass transfer properties of these fibers.
1,021 citations
TL;DR: A review of the recent progress of oil/water separation technologies based on filtration and absorption methods using various materials that possess surface superwetting properties is presented in this article.
Abstract: Oil/water separation is a field of high significance as it has direct practical implications for resolving the problem of industrial oily wastewater and other oil/water pollution. Therefore, the development of functional materials for efficient treatment of oil-polluted water is imperative. In this feature article, we have reviewed the recent progress of oil/water separation technologies based on filtration and absorption methods using various materials that possess surface superwetting properties. In each section, we present in detail representative work and describe the concepts, employed materials, fabrication methods, and the effects of their wetting/dewetting behaviors on oil/water separation. Finally, the challenges and future research directions of this promising research field are briefly discussed.
762 citations
TL;DR: An overview on the available natural polymer/calcium phosphate nanocomposite materials, their design, and properties is presented.
Abstract: Tissue engineering and regenerative medicine has been providing exciting technologies for the development of functional substitutes aimed to repair and regenerate damaged tissues and organs. Inspired by the hierarchical nature of bone, nanostructured biomaterials are gaining a singular attention for tissue engineering, owing their ability to promote cell adhesion and proliferation, and hence new bone growth, compared with conventional microsized materials. Of particular interest are nanocomposites involving biopolymeric matrices and bioactive nanosized fillers. Biodegradability, high mechanical strength, and osteointegration and formation of ligamentous tissue are properties required for such materials. Biopolymers are advantageous due to their similarities with extracellular matrices, specific degradation rates, and good biological performance. By its turn, calcium phosphates possess favorable osteoconductivity, resorbability, and biocompatibility. Herein, an overview on the available natural polymer/calcium phosphate nanocomposite materials, their design, and properties is presented. Scaffolds, hydrogels, and fibers as biomimetic strategies for tissue engineering, and processing methodologies are described. The specific biological properties of the nanocomposites, as well as their interaction with cells, including the use of bioactive molecules, are highlighted. Nanocomposites in vivo studies using animal models are also reviewed and discussed.
691 citations
TL;DR: Results indicated that novel 3D electrospun PCL/PLA blend nanofibrous scaffolds would be strongly favorable/desired for hMSCs osteogenic differentiation and cranial bone formation.
408 citations
Cites methods from "Biomimetic electrospun nanofibrous ..."
...To date, several technique s including phase separation, self-assembly, and electrospinning have been invest igated to prepare nanofibrous scaffolds as ECM substitutes [12-16]; among them, the electrospi nning technique has been paid particular attention because of its capability to make nanofib ers with morphological structures similar to those in natural ECM....
[...]
References
More filters
TL;DR: In this article, a comprehensive review is presented on the researches and developments related to electrospun polymer nanofibers including processing, structure and property characterization, applications, and modeling and simulations.
6,987 citations
TL;DR: It is shown here for the first time that the interdependence between surface roughness, reduced particle adhesion and water repellency is the keystone in the self-cleaning mechanism of many biological surfaces.
Abstract: The microrelief of plant surfaces, mainly caused by epicuticular wax crystalloids, serves different purposes and often causes effective water repellency. Furthermore, the adhesion of contaminating particles is reduced. Based on experimental data carried out on microscopically smooth (Fagus sylvatica L., Gnetum gnemon L., Heliconia densiflora Verlot, Magnolia grandiflora L.) and rough water-repellent plants (Brassica oleracea L., Colocasia esculenta (L.) Schott., Mutisia decurrens Cav., Nelumbo nucifera Gaertn.), it is shown here for the first time that the interdependence between surface roughness, reduced particle adhesion and water repellency is the keystone in the self-cleaning mechanism of many biological surfaces. The plants were artificially contaminated with various particles and subsequently subjected to artificial rinsing by sprinkler or fog generator. In the case of water-repellent leaves, the particles were removed completely by water droplets that rolled off the surfaces independent of their chemical nature or size. The leaves of N. nucifera afford an impressive demonstration of this effect, which is, therefore, called the “Lotus-Effect” and which may be of great biological and technological importance.
5,822 citations
TL;DR: An overview of electrospinning can be found in this article, where the authors focus on progress achieved in the last three years and highlight some potential applications associated with the remarkable features of electro-spun nanofibers.
Abstract: Electrospinning provides a simple and versatile method for generating ultrathin fibers from a rich variety of materials that include polymers, composites, and ceramics. This article presents an overview of this technique, with focus on progress achieved in the last three years. After a brief description of the setups for electrospinning, we choose to concentrate on the mechanisms and theoretical models that have been developed for electrospinning, as well as the ability to control the diameter, morphology, composition, secondary structure, and spatial alignment of electrospun nanofibers. In addition, we highlight some potential applications associated with the remarkable features of electrospun nanofibers. Our discussion is concluded with some personal perspectives on the future directions in which this wonderful technique could be pursued.
5,117 citations
TL;DR: This review presents an overview of the electrospinning technique with its promising advantages and potential applications, and focuses on varied applications of electrospun fibers in different fields.
3,932 citations
TL;DR: Electrospinning is a highly versatile method to process solutions or melts, mainly of polymers, into continuous fibers with diameters ranging from a few micrometers to a few nanometers, applicable to virtually every soluble or fusible polymer.
Abstract: Electrospinning is a highly versatile method to process solutions or melts, mainly of polymers, into continuous fibers with diameters ranging from a few micrometers to a few nanometers. This technique is applicable to virtually every soluble or fusible polymer. The polymers can be chemically modified and can also be tailored with additives ranging from simple carbon-black particles to complex species such as enzymes, viruses, and bacteria. Electrospinning appears to be straightforward, but is a rather intricate process that depends on a multitude of molecular, process, and technical parameters. The method provides access to entirely new materials, which may have complex chemical structures. Electrospinning is not only a focus of intense academic investigation; the technique is already being applied in many technological areas.
3,833 citations