Bioorganic & Medicinal Chemistry Letters
01 Jan 2014-
TL;DR: Ebselen is a relatively potent BBOX inhibitor, an observation which may in part reflect its cardioprotective properties.
Abstract: c-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate and Fe(II) dependent oxygenase that catalyses an essential step during carnitine biosynthesis in animals. BBOX is inhibited by ejection of structural zinc by a set of selenium containing analogues. Previous structural analyses indicated that an undisrupted N-terminal zinc binding domain of BBOX is required for catalysis. Ebselen is a relatively potent BBOX inhibitor, an observation which may in part reflect its cardioprotective properties.
Citations
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TL;DR: A picture emerges wherein LOX activity may contribute to the cellular pool of lipid hydroperoxides that initiate ferroptosis, but lipid autoxidation drives the cell death process.
Abstract: Lipoxygenases (LOXs) have been implicated as central players in ferroptosis, a recently characterized cell death modality associated with the accumulation of lipid hydroperoxides: the products of LOX catalysis To provide insight on their role, human embryonic kidney cells were transfected to overexpress each of the human isoforms associated with disease, 5-LOX, p12-LOX, and 15-LOX-1, which yielded stable cell lines that were demonstrably sensitized to ferroptosis Interestingly, the cells could be rescued by less than half of a diverse collection of known LOX inhibitors Furthermore, the cytoprotective compounds were similarly potent in each of the cell lines even though some were clearly isoform-selective LOX inhibitors The cytoprotective compounds were subsequently demonstrated to be effective radical-trapping antioxidants, which protect lipids from autoxidation, the autocatalytic radical chain reaction that produces lipid hydroperoxides From these data (and others reported herein), a picture emerges
339 citations
[...]
01 Jan 2016
Abstract: Thank you for downloading elements of style. As you may know, people have search hundreds times for their chosen novels like this elements of style, but end up in malicious downloads. Rather than reading a good book with a cup of coffee in the afternoon, instead they are facing with some infectious bugs inside their desktop computer. elements of style is available in our digital library an online access to it is set as public so you can download it instantly. Our digital library spans in multiple locations, allowing you to get the most less latency time to download any of our books like this one. Merely said, the elements of style is universally compatible with any devices to read.
169 citations
TL;DR: The structure of human δ-OR bound to the bifunctional μ- andδ-opioid receptor (OR) ligands is solved by serial femtosecond crystallography, revealing a cis-peptide bond between H-Dmt and Tic.
Abstract: Bifunctional μ- and δ-opioid receptor (OR) ligands are potential therapeutic alternatives, with diminished side effects, to alkaloid opiate analgesics. We solved the structure of human δ-OR bound to the bifunctional δ-OR antagonist and μ-OR agonist tetrapeptide H-Dmt-Tic-Phe-Phe-NH2 (DIPP-NH2) by serial femtosecond crystallography, revealing a cis-peptide bond between H-Dmt and Tic. The observed receptor-peptide interactions are critical for understanding of the pharmacological profiles of opioid peptides and for development of improved analgesics.
154 citations
01 Jan 2012
TL;DR: The present review is aimed at compiling data on promising phytochemicals from medicinal plants that have been tested in hepatotoxicity models using modern scientific system.
Abstract: Liver is a vital organ play a major role in metabolism and excretion of xenobiotics from the body. Liver injury or liver dysfunction is a major health problem that challenges not only health care professionals but also the pharmaceutical industry and drug regulatory agencies. Liver cell injury caused by various toxic chemicals (certain anti-biotic, chemotherapeutic agents, carbon tetrachloride (CCL4), thioacetamide (TAA) etc.), excessive alcohol consumption and microbes is well-studied. Herbal medicines have been used in the treatment of liver diseases for a long time. A number of herbal preparations are available in the market. The present review is aimed at compiling data on promising phytochemicals from medicinal plants that have been tested in hepatotoxicity models using modern scientific system.
97 citations
TL;DR: The literature survey as discussed by the authors highlights spectra and biological activity of transition metal complexes derived from Schiff bases of quinoxaline and discusses the extensive studies of synthesis, spectral, structural characterization, and biological activities of the metal complexes with heterocyclic Schiff bases.
Abstract: The literature survey highlights spectra and biological activity of transition metal complexes derived from Schiff bases of quinoxaline. The extensive studies of synthesis, spectral, structural characterization, and biological activities of the metal complexes with heterocyclic Schiff bases of quinoxaline are reviewed.
89 citations
References
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TL;DR: A picture emerges wherein LOX activity may contribute to the cellular pool of lipid hydroperoxides that initiate ferroptosis, but lipid autoxidation drives the cell death process.
Abstract: Lipoxygenases (LOXs) have been implicated as central players in ferroptosis, a recently characterized cell death modality associated with the accumulation of lipid hydroperoxides: the products of LOX catalysis To provide insight on their role, human embryonic kidney cells were transfected to overexpress each of the human isoforms associated with disease, 5-LOX, p12-LOX, and 15-LOX-1, which yielded stable cell lines that were demonstrably sensitized to ferroptosis Interestingly, the cells could be rescued by less than half of a diverse collection of known LOX inhibitors Furthermore, the cytoprotective compounds were similarly potent in each of the cell lines even though some were clearly isoform-selective LOX inhibitors The cytoprotective compounds were subsequently demonstrated to be effective radical-trapping antioxidants, which protect lipids from autoxidation, the autocatalytic radical chain reaction that produces lipid hydroperoxides From these data (and others reported herein), a picture emerges
339 citations
TL;DR: The Relative importance of multiple scale factors to oak tree mortality due to Japanese oak wilt disease and surrounding forest conditions and the findings using this dataset are published.
Abstract: Japanese oak wilt (Raffaelea quercivora) is a vector-borne disease transmitted by the flying ambrosia beetle, Platypus quercivorus, and causes mass mortality in the fagaceous species of Japan. The data described in this article are available in Mendeley Data, DOI: 10.17632/xwj98nb39r.1 [1] and include the mortality status of 1089 Quercus crispula and 846 Quercus serrata trees and surrounding forest conditions. The findings using this dataset were published in M. Oguro, S. Imahiro, S. Saito, T. Nakashizuka, Relative importance of multiple scale factors to oak tree mortality due to Japanese oak wilt disease, For. Ecol. Manag. (2015) doi:10.1016/j.foreco.2015.07.016 [2].
188 citations
[...]
01 Jan 2016
Abstract: Thank you for downloading elements of style. As you may know, people have search hundreds times for their chosen novels like this elements of style, but end up in malicious downloads. Rather than reading a good book with a cup of coffee in the afternoon, instead they are facing with some infectious bugs inside their desktop computer. elements of style is available in our digital library an online access to it is set as public so you can download it instantly. Our digital library spans in multiple locations, allowing you to get the most less latency time to download any of our books like this one. Merely said, the elements of style is universally compatible with any devices to read.
169 citations
TL;DR: The structure of human δ-OR bound to the bifunctional μ- andδ-opioid receptor (OR) ligands is solved by serial femtosecond crystallography, revealing a cis-peptide bond between H-Dmt and Tic.
Abstract: Bifunctional μ- and δ-opioid receptor (OR) ligands are potential therapeutic alternatives, with diminished side effects, to alkaloid opiate analgesics. We solved the structure of human δ-OR bound to the bifunctional δ-OR antagonist and μ-OR agonist tetrapeptide H-Dmt-Tic-Phe-Phe-NH2 (DIPP-NH2) by serial femtosecond crystallography, revealing a cis-peptide bond between H-Dmt and Tic. The observed receptor-peptide interactions are critical for understanding of the pharmacological profiles of opioid peptides and for development of improved analgesics.
154 citations
01 Jan 2012
TL;DR: The present review is aimed at compiling data on promising phytochemicals from medicinal plants that have been tested in hepatotoxicity models using modern scientific system.
Abstract: Liver is a vital organ play a major role in metabolism and excretion of xenobiotics from the body. Liver injury or liver dysfunction is a major health problem that challenges not only health care professionals but also the pharmaceutical industry and drug regulatory agencies. Liver cell injury caused by various toxic chemicals (certain anti-biotic, chemotherapeutic agents, carbon tetrachloride (CCL4), thioacetamide (TAA) etc.), excessive alcohol consumption and microbes is well-studied. Herbal medicines have been used in the treatment of liver diseases for a long time. A number of herbal preparations are available in the market. The present review is aimed at compiling data on promising phytochemicals from medicinal plants that have been tested in hepatotoxicity models using modern scientific system.
97 citations