Journal ArticleDOI
Bioproduction of resveratrol and stilbene derivatives by plant cells and microorganisms
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TLDR
Different available methods of trans-resveratrol production through recombinant microorganisms and plant cell suspensions are described and compared, with a focus on their respective advantages, limits and perspectives as a basis for scale-up in large culture volumes.About:
This article is published in Trends in Biotechnology.The article was published on 2009-12-01. It has received 182 citations till now. The article focuses on the topics: Bioproduction.read more
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Plant Polyphenols: Chemical Properties, Biological Activities, and Synthesis
TL;DR: This Review gives answers from a chemical perspective, summarizes the state of the art, and highlights the most significant advances in the field of polyphenol research.
Journal ArticleDOI
Technologies for Extraction and Production of Bioactive Compounds to be Used as Nutraceuticals and Food Ingredients: An Overview
G. Joana Gil-Chavez,José A. Villa,J. Fernando Ayala-Zavala,J. Basilio Heredia,D.R. Sepulveda,Elhadi M. Yahia,Gustavo A. González-Aguilar +6 more
TL;DR: The most commonly used methods for their extraction are the conventional liquid-liquid or solid-liquid extraction and the advanced methods include pressurized liquid extraction, subcritical and supercritical extractions, and microwave-and ultrasound-assisted extractions.
Journal ArticleDOI
Biosynthesis and Regulation of Phenylpropanoids in Plants
Yuxing Deng,Shanfa Lu +1 more
TL;DR: Phenylpropanoids are a large class of plant secondary metabolites derived from aromatic amino acids phenylalanine in most plants or tyrosine in partial monocots as discussed by the authors.
Journal ArticleDOI
Biosynthesis, metabolism, molecular engineering, and biological functions of stilbene phytoalexins in plants.
Philippe Jeandet,Bertrand Delaunois,Alexandra Conreux,David Donnez,Vitale Nuzzo,Sylvain Cordelier,Christophe Clément,Eric Courot +7 more
TL;DR: The biological significance of stilbenes in plants together with their biosynthesis pathway and their metabolism both by fungi and in planta is reviewed.
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Deciphering the role of phytoalexins in plant-microorganism interactions and human health.
Philippe Jeandet,Claire Hébrard,Marie-Alice Deville,Sylvain Cordelier,Stéphan Dorey,Aziz Aziz,Jérôme Crouzet +6 more
TL;DR: In this review, the key features of this diverse group of molecules, namely their chemical structures, biosynthesis, regulatory mechanisms, biological activities, metabolism and molecular engineering are presented.
References
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Journal ArticleDOI
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Jason G. Wood,Blanka Rogina,Siva Lavu,Konrad T. Howitz,Stephen L. Helfand,Marc Tatar,David A. Sinclair +6 more
TL;DR: It is shown that resveratrol and other STACs activate sirtuins from Caenorhabditis elegans and Drosophila melanogaster, and extend the lifespan of these animals without reducing fecundity, indicating that STacs slow metazoan ageing by mechanisms that may be related to caloric restriction.
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Elicitor signal transduction leading to production of plant secondary metabolites.
TL;DR: Progress made on several aspects of elicitor signal transduction leading to production of plant secondary metabolites are summarized, including the integration of multiple signaling pathways into or by transcription factors, as well as the linkage of the above signal components in eliciting network through protein phosphorylation and dephosphorylation.
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High absorption but very low bioavailability of oral resveratrol in humans
TL;DR: The dietary polyphenol resveratrol has been shown to have chemopreventive activity against cardiovascular disease and a variety of cancers in model systems, but it is not clear whether the drug reaches the proposed sites of action in vivo after oral ingestion, especially in humans.
Journal Article
Role of Resveratrol in Prevention and Therapy of Cancer: Preclinical and Clinical Studies
Bharat B. Aggarwal,Anjana Bhardwaj,Rishi S. Aggarwal,Navindra P. Seeram,Shishir Shishodia,Yasunari Takada +5 more
TL;DR: In vivo, resveratrol blocks the multistep process of carcinogenesis at various stages: it blocks carcinogen activation by inhibiting aryl hydrocarbon-induced CYP1A1 expression and activity, and suppresses tumor initiation, promotion and progression.
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Plant cell cultures: Chemical factories of secondary metabolites
TL;DR: The production of the pungent food additive capsaicin, the natural colour anthocyanin and the natural flavour vanillin is described in detail.