Bioreactor engineering of stem cell environments
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TLDR
The current advances in engineering stem cell environments using novel biomaterials and bioreactor technologies are discussed and the challenges the field is currently facing with regard to the translation of stem cell based therapies into the clinic are reflected.About:
This article is published in Biotechnology Advances.The article was published on 2013-11-15 and is currently open access. It has received 55 citations till now. The article focuses on the topics: Modern medicine & Stem cell.read more
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Three-dimensional in vitro tumor models for cancer research and drug evaluation.
TL;DR: A review of 3D tumor models employing tissue engineering principles can be found in this article, where the authors highlight the profound differences in responses from 3D in vitro tumors and conventional monolayer cultures.
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Extracellular matrix in lung development, homeostasis and disease
Yong Zhou,Jeffrey C. Horowitz,Alexandra Naba,Namasivayam Ambalavanan,Kamran Atabai,Jenna L. Balestrini,Peter B. Bitterman,Richard A. Corley,Bi-Sen Ding,Adam J. Engler,Kirk C. Hansen,James S. Hagood,Farrah Kheradmand,Qing S. Lin,Enid Neptune,Laura E. Niklason,Luis A. Ortiz,William C. Parks,Daniel J. Tschumperlin,Eric S. White,Harold A. Chapman,Victor J. Thannickal +21 more
TL;DR: This review assesses the current state of lung ECM biology, including fundamental advances in ECM composition, dynamics, topography, and biomechanics; the role of the ECM in normal and aberrant lung development, adult lung diseases and autoimmunity; andECM in the regulation of the stem cell niche.
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In vitro three-dimensional bone tissue models: from cells to controlled and dynamic environment.
TL;DR: This review focuses on state-of-the-art and the current advances in the development of 3D culture systems for bone biology research, and details main characteristics and challenges associated with its three main components, that is, scaffold, cells, and perfusion bioreactor systems.
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HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease.
TL;DR: The project team is developing an integrated microphysiological platform with functionally connected vascular, liver and cardiac microtissues derived from a single line of human pluripotent stem cells that enables functional representation of human physiology in conjunction with real-time biological readouts and compatibility with high-throughput/high-content analysis.
Pharmaceutical applications of embryonic stem cells
TL;DR: A review of the current status and future prospects for this exciting field and encourage pharmaceutical scientists to play a role in directing its development can be found in this paper, where the focus is on understanding the signalling systems and transcription factors that drive differentiation, characterisation and isolation of precursor cells, and establishing methods to improve the homogeneity of differentiated cells derived from ESCs.
References
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Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Kazutoshi Takahashi,Koji Tanabe,Mari Ohnuki,Megumi Narita,Tomoko Ichisaka,Kiichiro Tomoda,Shinya Yamanaka +6 more
TL;DR: It is demonstrated that iPS cells can be generated from adult human fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc.
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Embryonic Stem Cell Lines Derived from Human Blastocysts
James A. Thomson,Joseph Itskovitz-Eldor,Sander S. Shapiro,Michelle A. Waknitz,Swiergiel Jennifer J,Vivienne S. Marshall,Jeffrey M. Jones +6 more
TL;DR: Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but do not characterize other early lineages.
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Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system
Brent A. Reynolds,Samuel Weiss +1 more
TL;DR: Cells of the adult mouse striatum have the capacity to divide and differentiate into neurons and astrocytes.