Journal ArticleDOI
Biosynthesis of salsolinol, a tetrahydroisoquinoline alkaloid, in healthy subjects.
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TLDR
The absence of salsolinol in the urine of one subject after Madopar administration seems to indicate that the biological system(s) involved in the reduction of the C = N bond in 1,2-dehydrosalsol can be missing or not, or poorly, functional in some individuals, and suggests that there is no alternative pathway for the formation of salolinol for healthy volunteers.Abstract:
The R enantiomer of salsolinol was detected in the urine of two out of six healthy subjects, whereas 1,2-dehydrosalsolinol was present in the urine of all the subjects. (S)-salsolinol was never detected. Administration of Madopar for 7 days resulted in the presence of large amounts of (R)- and (S)-salsolinol in the urine of five out of the six subjects, the urinary excretion of 1,2-dehydrosalsolinol being generally not markedly increased.read more
Citations
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A novel enzyme enantio-selectively synthesizes (R)salsolinol, a precursor of a dopaminergic neurotoxin, N-methyl(R)salsolinol.
TL;DR: The isolation and characterization of a novel enzyme, which enantio-selectively synthesizes (R)salsolinol from dopamine and acetaldehyde is reported, and the possible function of this enzyme under physiological and pathological conditions in the brain is discussed.
Journal ArticleDOI
Dopamine-derived endogenous 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl-(R)-salsolinol, induced parkinsonism in rat: biochemical, pathological and behavioral studies
Makoto Naoi,Wakako Maruyama,Philippe Dostert,Yoshio Hashizume,Daiichiro Nakahara,Tsutomu Takahashi,Miyuki Ota +6 more
TL;DR: The results demonstrate the selective cytotoxicity of NM(R)Sal to the dopamine neurons in the substantia nigra, and the possible involvement of this 6,7-dihydroxy-isoquinoline in the pathogenesis of Parkinson's disease is discussed.
Journal ArticleDOI
Cyclosporin inhibition of apoptosis induced by mitochondrial complex I toxins
TL;DR: Apoptosis induced by inhibitors of mitochondrial complex I is probably mediated by permeability pore opening and collapse of the mitochondrial membrane potential, and this observation may allow the development of novel neuroprotective strategies in disorders that may involve mitochondrial dysfunction and apoptotic cell death.
Journal ArticleDOI
Catecholamines oxidation by xanthine oxidase.
TL;DR: Dopamine and structurally related catecholamines in the presence of hydrogen peroxide are oxidized in vitro by xanthine oxidase producing the corresponding melanin pigments, and the kinetic parameters of the reaction are calculated.
Journal ArticleDOI
Dopamine-derived salsolinol derivatives as endogenous monoamine oxidase inhibitors: Occurrence, metabolism and function in human brains
TL;DR: The role of dopamine-derived endogenous salsolinol derivatives as the regulators of neurotransmission, dopaminergic neurotoxins and neuro-hormonal transmitters in the human brain is discussed.
References
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Journal ArticleDOI
Fluoreszenzmethoden zur histochemischen Sichtbarmachung von Monoaminen. 1. Identifizierung der fluoreszierenden Produkte aus Modellversuchen mit 6,7-Dimethoxyisochinolinderivaten und Formaldehyd
H. Corrodi,N. Å. Hillarp +1 more
TL;DR: When primary or secondary catecholamines are treated with formaldehyde gas in a dried protein layer, strong fluorescence appears which is used for histochemical identification of these amines in central and peripheral adrenergic nerves.
Journal ArticleDOI
Fluoreszenzenzmethoden zur histochemischen Sichtbarmachung von Monoaminen. 2.. Identifizierung des fluoreszierenden Produktes aus Dopamin und Formaldehyd
TL;DR: In this article, it was shown that dopamine [β-(3,4-dihydroxyphenyl)-ethylamine can be converted into highly fluorescent products by treatment with formaldehyde gas, under the condition that the reaction takes place in a dry protein containing layer.
Journal ArticleDOI
Possible new metabolites mediating actions of L-dopa.
TL;DR: The type reaction described here has been demonstrated in vivo and it is conceivable that a benzyltetrahydroisoquinoline, derived from L-dopa in vivo, has at least some of the pharmacological activities ascribed to this amino-acid in Parkinson's disease.
Journal ArticleDOI
Dopamine-derived alkaloids in alcoholism and in Parkinson's and Huntington's diseases.
TL;DR: The changes in monoamine oxidase activity and the nigrostriatal concentrations of dopamine and homovanillic acid in Parkinson's and Huntington's diseases and in alcoholism are reviewed and the possible modifications found might cause or contribute to changes in mental and/or neurophysiological states in these pathological situations.
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