Bismuth Phosphinates: Temperature-Dependent Formation of a Macrocycle and 1D Coordination Polymer
19 Oct 2015-Phosphorus Sulfur and Silicon and The Related Elements (Taylor & Francis)-Vol. 190, Iss: 12, pp 2134-2141
TL;DR: In this paper, the reaction of Ph3Bi with a sterically hindered phosphinic acid, 1,1,2,3,3-pentamethyltrimethylene phosphinic acid, {cycP(O)OH·2H2O}, at two different temperatures, one at refluxing conditions and another at room temperature, in tetrahydrofuran has been investigated.
Abstract: The reaction of Ph3Bi with a sterically hindered phosphinic acid, 1,1,2,3,3-pentamethyltrimethylene phosphinic acid, {cycP(O)OH·2H2O}, at two different temperatures, one at refluxing conditions and another at room temperature, in tetrahydrofuran has been investigated. At refluxing conditions, cleavage of two Bi-C bonds (of BiPh3) leads to the formation of a 16-member macrocycle [(PhBi)4(cycPO2)8] (1). On the other hand, the reaction at room temperature leads to the cleavage of one Bi-C bond only, affording a 1D polymer [(Ph2Bi)(cycPO2)]n, ((1,1,2,3,3-pentamethyltrimethylene phosphinate is denoted as cycPO2) (2). Both the complexes were characterized by single crystal X-ray diffraction. In both complexes the phosphinate ligands are present in an anisobidentate (bridging) coordination mode.
Citations
More filters
••
TL;DR: In this paper , the structure-activity relationship in di-aryl bismuth phosphinates on antibacterial activity and cytotoxicity was studied and a series of complexes were synthesized and characterised.
Abstract: To study and evaluate the structure-activity relationships in di-aryl bismuth phosphinates on antibacterial activity and cytotoxicity a series of complexes containing ortho-methoxyphenyl, meta-methoxyphenyl, meta-tolyl and para-tolyl aryl groups; [Bi(o-MeOPh)2(O(O)P(H)Ph)]n1, [Bi(o-MeOPh)2(O(O)PPh2)]n2, [Bi(o-MeOPh)2(O(O)P(p-MeOPh)2)]n3, [Bi(m-MeOPh)2(O(O)P(H)Ph)]n4, [Bi(m-MeOPh)2(O(O)PPh2)]n5, [Bi(m-MeOPh)2(O(O)P(p-MeOPh)2)]n6, [Bi(m-tol)2(O(O)P(H)Ph)]n7, [Bi(m-tol)2(O(O)PPh2)]n8, [Bi(m-tol)2(O(O)P(p-MeOPh)2)]n9, [Bi(p-tol)2(O(O)P(H)Ph)]n10, [Bi(p-tol)2(O(O)PPh2)]n11 and [Bi(p-tol)2(O(O)P(p-MeOPh)2)]n12, were synthesised and characterised. Complexes 4, 7, 8, 10 and 11 were structurally authenticated by X-ray crystallography. Evaluation of their antibacterial activity towards methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa) showed that the bismuth bound aryl group has a profound influence on activity, with the o-MeOPh complexes 1-3 showing very little activity while the m-MeOPh complexes have the greatest activity towards MRSA and VRE in the range of 0.63 to 1.25 μM. Viability studies with Cos-7 cells showed that the di-aryl bismuth complexes 1-12 are less cytotoxic than their di-phenyl bismuth analogues, with a general trend of toxicity observed as p-tolyl > m-tolyl > m-methoxyphenyl > o-methoxyphenyl. The large difference in Cos-7 viability for complexes 1 (IC50 > 80 μM) and 4 (IC50 14.0 μM) was further investigated through bismuth uptake studies, where there was no obvious difference in Cos-7 bismuth uptake at 5 μM. This suggests that the bismuth-bound aryl group has a significant impact on biological activity, which is then further mediated by other ligands.
1 citations
••
TL;DR: In this paper , four cadmium phosphinate complexes were synthesized based on Bis-[α-hydroxy(p-methylphenyl)methyl]phosphinic acid (L) ligand.
•
30 Mar 2017TL;DR: In this paper, a method for the production of bismuth perfluoroalkylphosphinates as Lewis acid catalysts was described, and the compounds and the method for their production were described.
Abstract: The invention relates to bismuth perfluoroalkylphosphinates as Lewis acid catalysts, the compounds and a method for the production thereof. ArxBi[OP(O)(Rf)2]3 -x (la), Ar3Bi[OP(O)(Rf)2]2 (Ib).
References
More filters
••
TL;DR: OLEX2 seamlessly links all aspects of the structure solution, refinement and publication process and presents them in a single workflow-driven package, with the ultimate goal of producing an application which will be useful to both chemists and crystallographers.
Abstract: New software, OLEX2, has been developed for the determination, visualization and analysis of molecular crystal structures. The software has a portable mouse-driven workflow-oriented and fully comprehensive graphical user interface for structure solution, refinement and report generation, as well as novel tools for structure analysis. OLEX2 seamlessly links all aspects of the structure solution, refinement and publication process and presents them in a single workflow-driven package, with the ultimate goal of producing an application which will be useful to both chemists and crystallographers.
19,990 citations
•
01 Jan 2003
TL;DR: In this paper, the authors present a method for the synthesis of organic compounds using Spectroscopic methods and Spectral Spectral Methods (SSTM) with a focus on alicyclic and aliphatic compounds.
Abstract: 1. Organic synthesis 2. Experimental techniques. 3. Spectroscopic methods. 4. Solvents and reagents. 5. Aliphatic compounds. 6. Aromatic compounds. 7. Selected alicyclic compounds. 8. Selected heterocyclic compounds. 9. Investigation and characterisation of organic compounds. 10. Physical constants of organic compounds.
6,578 citations
••
523 citations
••
TL;DR: The investigation of bismuth interactions with potential targeting biomolecules, including peptides, proteins and enzymes will lead to an understanding of the mechanism of action of bISMuth-containing complexes and in turn to the further application ofbismuth in medicine.
263 citations
••
TL;DR: Bismuth compounds are used for the treatment of gastrointestinal disorders and may also be useful for other diseases as discussed by the authors, however, they exhibit a highly variable coordination number (3-10) and often an irregular coordination geometry.
249 citations