Blockade of the Vascular Endothelial Growth Factor Stress Response Increases the Antitumor Effects of Ionizing Radiation
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Cites background from "Blockade of the Vascular Endothelia..."
...Several growth factors, such as tissue growth factor(TGF- ), epidermal growth factor (EGF), and plateletderived growth factor BB (PDGF-BB) induce VEGF-A mRNA expression....
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...Knowing that PDGF is released from platelets following tissue injury, it is possible that VEGF-C is induced in wounds, contributing to the repair of tissue injury....
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...Benjamin LE, Hemo I, and Keshet E (1998) A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF....
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...They mainly block several subtypes of the VEGFR and also other tyrosine kinase receptors such as KIT, PDGF receptor, fibroblast growth factor receptor 1, Tie-2, and FLT3 (Laird et al., 2000, 2002; Wedge et al., 2000; Wood et al., 2000)....
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...It has been shown that VEGF-A mRNA is induced in vivo in wounds by PDGF in fibroblasts and by keratinocyte growth factor in epidermal keratinocytes (Enholm et al., 1997)....
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References
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"Blockade of the Vascular Endothelia..." refers methods in this paper
...Northern Blots. Total RNA was isolated from cultured cells and tumor tissue by the guanidine thiocyanate method ( 16 ) using Trizol LS (Life Sciences, Inc.)....
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"Blockade of the Vascular Endothelia..." refers background in this paper
...In normal tissues, angiogenesis is tightly regulated by the balance between angiogenic and antiangiogenic factors ( 1 )....
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"Blockade of the Vascular Endothelia..." refers result in this paper
...By day 6, consistent with previous observations (5, 6, 8, 9 ), treatment with anti-VEGF alone produced a 42.6% reduction in tumor volume (796 6 41 mm3; P 5 0.004)....
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