Journal ArticleDOI
Bowel dysfunction after low anterior resection with and without neoadjuvant therapy for rectal cancer: a population-based cross-sectional study.
Reads0
Chats0
TLDR
Bowel dysfunction was assessed after low anterior resection with and without neoadjuvant therapy for rectal cancer using a novel symptom‐based scoring system correlated with quality of life.Abstract:
Aim
Bowel dysfunction was assessed after low anterior resection with and without neoadjuvant therapy (NT) for rectal cancer using a novel symptom-based scoring system correlated with quality of life.
Method
We identified all patients who underwent curative resection for rectal cancer in Denmark between 2001 and 2007. A questionnaire on bowel function and quality of life, including the recently validated low anterior resection syndrome score (LARS score; range 0–42) was administered to recurrence-free patients in 2009. We used multivariate analysis to examine the association between major LARS (LARS score ≥ 30) and a number of patient and treatment-related factors.
Results
Of 1087 eligible patients, 980 agreed to participate and, of these, 938 were included in the analysis. Major LARS was observed in 41%. The use of NT (OR = 2.48; 95% CI: 1.73–3.55), long-course chemoradiotherapy vs short-course radiotherapy (OR = 0.90; 95% CI: 0.44–1.87), total mesorectal excision (TME) vs partial mesorectal excision (PME) (OR = 2.31; 95% CI: 1.69–3.16), anastomotic leakage (OR = 2.06; 95% CI: 0.93–4.55), age ≤ 64 years at surgery (OR = 1.90; 95% CI: 1.43–2.51) and female gender (OR = 1.35; 95% CI 1.02–1.79) were associated with major LARS. No association was found between major LARS and the time since surgery (OR = 0.78; 95% CI: 0.59–1.04) or neorectal reconstruction (colonic pouch vs straight colorectal or side-to-end anastomosis (OR = 0.96; 95% CI: 0.63–1.46).
Conclusion
Severe bowel dysfunction is a frequent long-term outcome after resection for rectal cancer. Use of NT, regardless of a long- or short-course protocol, and TME (compared with PME) are strong independent risk factors for major LARS.read more
Citations
More filters
Journal ArticleDOI
High-dose chemoradiotherapy and watchful waiting for distal rectal cancer: a prospective observational study
Ane L Appelt,John Pløen,Henrik Harling,Frank Jensen,Lars Henrik Jensen,Jens Christian Riis Jørgensen,Jan Lindebjerg,Søren Rafael Rafaelsen,Anders Jakobsen +8 more
TL;DR: High-dose chemoradiotherapy and watchful waiting might be a safe alternative to abdominoperineal resection for patients with distal rectal cancer.
Journal ArticleDOI
Impact of bowel dysfunction on quality of life after sphincter‐preserving resection for rectal cancer
TL;DR: The aim of this study was to examine the extent of bowel dysfunction and impact on health‐related QoL after curative sphincter‐preserving resection for rectal cancer.
Journal ArticleDOI
Bowel Function 14 Years After Preoperative Short-Course Radiotherapy and Total Mesorectal Excision for Rectal Cancer: Report of a Multicenter Randomized Trial
Tina Yen-Ting Chen,Lisette M. Wiltink,Remi A. Nout,Elma Meershoek-Klein Kranenbarg,Søren Laurberg,Corrie A.M. Marijnen,Cornelis J.H. van de Velde +6 more
TL;DR: A considerable proportion of nonstoma patients endured major LARS years after total mesorectal excision with or without preoperative short-course radiotherapy for rectal cancer, and the association of bowel dysfunction with health-related quality of life (HRQL).
Journal ArticleDOI
A meta-analysis of the prevalence of Low Anterior Resection Syndrome and systematic review of risk factors.
TL;DR: There is significant prevalence of Low Anterior Resection Syndrome following oncological rectal resection and a low anastomotic height or history of radiotherapy are major risk factors.
Journal ArticleDOI
Long-Term and Latent Side Effects of Specific Cancer Types
TL;DR: The treatment side effects for several of the most prevalent cancers in the United States are summarized and contribute to worse quality of life, morbidity, and mortality for cancer survivors.
References
More filters
Journal ArticleDOI
The mesorectum in rectal cancer surgery--the clue to pelvic recurrence?
TL;DR: Five cases are described where minute foci of adenocarcinoma have been demonstrated in the mesorectum several centimetres distal to the apparent lower edge of a rectal cancer, and these operations have been carried out as a part of over 100 consecutive anterior resections.
Journal ArticleDOI
Recurrence and survival after total mesorectal excision for rectal cancer.
Richard J. Heald,R.D.H. Ryall +1 more
TL;DR: On this evidence, it is often safe to limit mural clearance and thus preserve the anal sphincters, provided that the mesorectum is excised intact with the cancer.
Journal ArticleDOI
The prevalence of pelvic floor disorders and their relationship to gender, age, parity and mode of delivery.
TL;DR: To define the prevalence of pelvic floor disorders in a non‐institutionalised community and to determine the relationship to gender, age, parity and mode of delivery.
Journal ArticleDOI
Late side effects of short-course preoperative radiotherapy combined with total mesorectal excision for rectal cancer : Increased bowel dysfunction in irradiated patients - A dutch colorectal cancer group study
Koen C.M.J. Peeters,C.J.H. van de Velde,J.W.H. Leer,Hendrik Martijn,Jan M. C. Junggeburt,E. Klein Kranenbarg,W.H. Steup,T. Wiggers,Heidi Rütten,Corrie A.M. Marijnen +9 more
TL;DR: Although preoperative short-term radiotherapy for rectal cancer results in increased local control, there is more long-term bowel dysfunction in irradiated patients than in patients who undergo TME alone.
Journal ArticleDOI
Epidemiology. When an entire country is a cohort.
TL;DR: Denmark has gathered more data on its citizens than any other country, and scientists are pushing to make this vast array of statistics even more useful by easing restrictions on the use of data coded by personal identification numbers.