Brain Metabolic Profile after Intranasal vs. Intraperitoneal Clomipramine Treatment in Rats with Ultrasound Model of Depression
Olga Abramova,Yana Zorkina,Timur Syunyakov,E. A. Zubkov,Valeria Ushakova,Artemiy S. Silantyev,Kristina Soloveva,Olga I. Gurina,Alexander G. Majouga,Anna Morozova,Vladimir P. Chekhonin +10 more
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TLDR
In this paper, the brain metabolome after antidepressant therapy is poorly understood and had not been performed for different routes of drug administration before the present study, and the brain metabolites in the frontal cortex and hippocampus were analyzed with liquid chromatography.Abstract:
Background: Molecular mechanisms of depression remain unclear. The brain metabolome after antidepressant therapy is poorly understood and had not been performed for different routes of drug administration before the present study. Rats were exposed to chronic ultrasound stress and treated with intranasal and intraperitoneal clomipramine. We then analyzed 28 metabolites in the frontal cortex and hippocampus. Methods: Rats’ behavior was identified in such tests: social interaction, sucrose preference, forced swim, and Morris water maze. Metabolic analysis was performed with liquid chromatography. Results: After ultrasound stress pronounced depressive-like behavior, clomipramine had an equally antidepressant effect after intranasal and intraperitoneal administration on behavior. Ultrasound stress contributed to changes of the metabolomic pathways associated with pathophysiology of depression. Clomipramine affected global metabolome in frontal cortex and hippocampus in a different way that depended on the route of administration. Intranasal route was associated with more significant changes of metabolites composition in the frontal cortex compared to the control and ultrasound groups while the intraperitoneal route corresponded with more profound changes in hippocampal metabolome compared to other groups. Since far metabolic processes in the brain can change in many ways depending on different routes of administration, the antidepressant therapy should also be evaluated from this point of view.read more
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Peptide LCGA-17 Attenuates Behavioral and Neurochemical Deficits in Rodent Models of PTSD and Depression
A. V. Malyshev,I. Sukhanova,Valeria Ushakova,Ya. A. Zorkina,Olga Abramova,Anna Morozova,E. A. Zubkov,Nikita A. Mitkin,Vsevolod V. Pavshintsev,I. Doronin,Vasilina R. Gedzun,Gennady A. Babkin,Sergio Álvarez Sánchez,Miah D Baker,Colin N. Haile +14 more
TL;DR: Results support the further development of the LCGA-17 peptide as a rapid-acting anxiolytic and antidepressant candidate and restore the norepinephrine levels in the hippocampus following stress.
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Preparation of Protein Aerogel Particles for the Development of Innovative Drug Delivery Systems
Daria Lovskaya,Anna Bezchasnyuk,Maria Mochalova,Pavel Tsygankov,A. E. Lebedev,Ya. A. Zorkina,E. Zubkov,A. Ochneva,O. Gurina,Artemiy S. Silantyev,Alexander G. Majouga,Natalia Menshutina +11 more
TL;DR: In this article , the results of experimental studies have shown that changing the dispersion method makes it possible to control the structural characteristics of protein aerogel particles, which can be applied to obtain innovative nasal drug delivery systems for the treatment of socially significant diseases.
Journal ArticleDOI
Antidepressant Effect of Neuropeptide Y in Models of Acute and Chronic Stress
Nika Andriushchenko,Kira Nebogina,Ya. A. Zorkina,Olga Abramova,E. A. Zubkov,A. Ochneva,Valeria Ushakova,Konstantin Pavlov,Olga I. Gurina,Vladimir P. Chekhonin,Anna Morozova +10 more
TL;DR: The hypothesis that neuropeptide Y can enhance the effect of a classical antidepressant was not confirmed, and a protective effect of intranasal NY in a model of acute stress, which was comparable to the antidepressant effect of clomipramine.
Journal ArticleDOI
Chitosan Aerogel Particles as Nasal Drug Delivery Systems
Natalia Menshutina,Alexander G. Majouga,A.G. Uvarova,Daria Lovskaya,Pavel Tsygankov,Maria Mochalova,Olga Abramova,Valeria Ushakova,Anna Morozova,Artemiy S. Silantyev +9 more
TL;DR: In this paper , the results of a study of the processes for obtaining chitosan aerogel particles that are promising as nasal or inhalation drug delivery systems are presented.
Journal ArticleDOI
Intranasal neuropeptide Y is most effective in some aspects of acute stress compared to melatonin, oxytocin and orexin
E. A. Zubkov,Olga Abramova,Ya. A. Zorkina,A. Ochneva,Valeria Ushakova,Anna Morozova,O. Gurina,Alexander G. Majouga,Vladimir P. Chekhonin +8 more
TL;DR: In this paper , the effects of a single intranasal administration of clomipramine with effects of four neuropeptides, melatonin, oxytocin, orexin, and Neuropeptide Y, were compared in an acute stress model.
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