Brainstem respiratory networks: building blocks and microcircuits
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TLDR
New insights into the spatial-functional organization of key neural microcircuits of this CPG allow the generation of multiple rhythmic breathing patterns and adaptive switching between them, depending on physiological or pathophysiological conditions.About:
This article is published in Trends in Neurosciences.The article was published on 2013-03-01 and is currently open access. It has received 323 citations till now. The article focuses on the topics: Central pattern generator.read more
Citations
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Journal ArticleDOI
Vagal Afferent Innervation of the Airways in Health and Disease.
TL;DR: Historical and state-of-the-art concepts in airway sensory neurobiology are discussed and mechanisms underlying how vagal sensory pathways become dysfunctional in pathological conditions are explored.
Journal ArticleDOI
Neural Control of Breathing and CO2 Homeostasis
TL;DR: The neural circuits underlying central command and muscle afferent control of breathing remain elusive and represent a fertile area for future investigation.
OtherDOI
Regulation of Breathing and Autonomic Outflows by Chemoreceptors
TL;DR: The effects of these various pathologies on brainstem cardiorespiratory networks are discussed, special consideration being given to the interactions between central and peripheral chemoreflexes.
Journal ArticleDOI
C1 neurons: the body's EMTs
Patrice G. Guyenet,Ruth L. Stornetta,Genrieta Bochorishvili,Seth D. DePuy,Peter G R Burke,Stephen B. G. Abbott +5 more
TL;DR: The C1 neurons reside in the rostral and intermediate portions of the ventrolateral medulla (RVLM, IVLM) as mentioned in this paper and use glutamate as a fast transmitter and synthesize catecholamines plus various neuropeptides.
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Physiological noise in brainstem FMRI.
TL;DR: This Methods Article will provide a practical introduction to the techniques used to correct for the presence of physiological noise in time series fMRI data, and advice on modeling noise sources is given.
References
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Book
Rhythms of the brain
TL;DR: The brain's default state: self-organized oscillations in rest and sleep, and perturbation of the default patterns by experience.
Journal ArticleDOI
Pre-Botzinger Complex: A Brainstem Region That May Generate Respiratory Rhythm in Mammals
TL;DR: The respiratory rhythm in the mammalian neonatal nervous system may result from a population of conditional bursting pacemaker neurons in the pre-Bötzinger Complex.
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The Story of Rett Syndrome: From Clinic to Neurobiology
Maria H. Chahrour,Huda Y. Zoghbi +1 more
TL;DR: To investigate the potential for restoring neuronal function in RTT patients, it is essential to identify MeCP2 targets or modifiers of the phenotype that can be therapeutically modulated.
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Biological Pattern Generation: The Cellular and Computational Logic of Networks in Motion
TL;DR: The mode of operation of these pattern generator networks is discussed and the neural mechanisms through which they are selected and activated are considered, and the utility of computational models in analysis of the dynamic actions of these motor networks are outlined.
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Looking for inspiration: new perspectives on respiratory rhythm.
TL;DR: New evidence is evaluated and interpreted for two separate brainstem respiratory oscillators and for the essential role of emergent network properties in rhythm generation in mammalian respiratory rhythm generation.