Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): objectives and design.
Estela M. L. Aquino,Sandhi Maria Barreto,Isabela M. Benseñor,Marilia Sá Carvalho,Dóra Chor,Bruce Bartholow Duncan,Paulo A. Lotufo,José Geraldo Mill,Maria del Carmen Bisi Molina,Eduardo Luiz Andrade Mota,Valéria Maria de Azeredo Passos,Maria Inês Schmidt,Moyses Szklo +12 more
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TLDR
The authors delineate the study's objectives, principal methodological features, and timeline, and confirm that long-term biologic sample storage will allow investigation of biomarkers that may predict cardiovascular diseases and diabetes.Abstract:
Although low- and middle-income countries still bear the burden of major infectious diseases, chronic noncommunicable diseases are becoming increasingly common due to rapid demographic, epidemiologic, and nutritional transitions. However, information is generally scant in these countries regarding chronic disease incidence, social determinants, and risk factors. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) aims to contribute relevant information with respect to the development and progression of clinical and subclinical chronic diseases, particularly cardiovascular diseases and diabetes. In this report, the authors delineate the study's objectives, principal methodological features, and timeline. At baseline, ELSA-Brasil enrolled 15,105 civil servants from 5 universities and 1 research institute. The baseline examination (2008-2010) included detailed interviews, clinical and anthropometric examinations, an oral glucose tolerance test, overnight urine collection, a 12-lead resting electrocardiogram, measurement of carotid intima-media thickness, echocardiography, measurement of pulse wave velocity, hepatic ultrasonography, retinal fundus photography, and an analysis of heart rate variability. Long-term biologic sample storage will allow investigation of biomarkers that may predict cardiovascular diseases and diabetes. Annual telephone surveillance, initiated in 2009, will continue for the duration of the study. A follow-up examination is scheduled for 2012-2013.read more
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Cohort Profile: Longitudinal Study of Adult Health (ELSA-Brasil)
Maria Inês Schmidt,Bruce Bartholow Duncan,José Geraldo Mill,Paulo A. Lotufo,Dóra Chor,Sandhi Maria Barreto,Estela M. L. Aquino,Valéria Maria de Azeredo Passos,Sheila Maria Alvim Matos,Maria del Carmen Bisi Molina,Marilia Sá Carvalho,Isabela M. Benseñor +11 more
TL;DR: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) aims to contribute relevant information regarding the development and progression of clinical and subclinical chronic diseases, particularly cardiovascular diseases and diabetes, in one such setting.
Journal ArticleDOI
The relationship between mental and physical health: Insights from the study of heart rate variability
TL;DR: This work shows that otherwise healthy, unmedicated patients with these disorders display reduced resting-state HRV, and that pharmacological treatments do not ameliorate these reductions, and proposes a working model for the effects of mood disorders, comorbid conditions, and their treatments to help guide future research activities.
Journal ArticleDOI
Enfermedades crónica no transmisibles en Brasil: prioridad para enfrentar e investigar
Bruce Bartholow Duncan,Dóra Chor,Estela M. L. Aquino,Isabela M. Benseñor,José Geraldo Mill,Maria Inês Schmidt,Paulo A. Lotufo,Álvaro Vigo,Sandhi Maria Barreto +8 more
TL;DR: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), a cohort study of 15,105 Brazilian public servants reflects the reality of high prevalences of diabetes, hypertension and the main chronic diseases risk factors.
Journal ArticleDOI
Prevalence, Awareness, Treatment and Influence of Socioeconomic Variables on Control of High Blood Pressure: Results of the ELSA-Brasil Study.
Dóra Chor,Antonio Luiz Pinho Ribeiro,Marilia Sá Carvalho,Bruce Bartholow Duncan,Paulo A. Lotufo,Aline Araújo Nobre,Estela M. L. Aquino,Maria Inês Schmidt,Rosane Harter Griep,Maria del Carmen Bisi Molina,Sandhi Maria Barreto,Valéria Maria de Azeredo Passos,Isabela M. Benseñor,Sheila Maria Alvim Matos,José Geraldo Mill +14 more
TL;DR: High blood pressure (HBP) is the leading risk factor for years of life lost in Brazil and Socioeconomic and racial inequality—as measured by different indicators—are strongly associated with HBP control, beyond the expected influence of health services access.
Journal ArticleDOI
Effects of Depression, Anxiety, Comorbidity, and Antidepressants on Resting-State Heart Rate and Its Variability: An ELSA-Brasil Cohort Baseline Study
Andrew H. Kemp,Andre R. Brunoni,Itamar S. Santos,Maria Angélica Nunes,Eduardo Miranda Dantas,Roberta Carvalho de Figueiredo,Alexandre Costa Pereira,Antonio Luiz Pinho Ribeiro,José Geraldo Mill,Rodrigo Varejão Andreão,Julian F. Thayer,Isabela M. Benseñor,Paulo A. Lotufo +12 more
TL;DR: The findings may, in part, underpin epidemiological findings of increased risk for cardiovascular morbidity and mortality, highlighting the importance of cardiovascular risk reduction strategies.
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