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Breaking prolonged sitting reduces postprandial glycemia in healthy, normal-weight adults: a randomized crossover trial

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TLDR
Regular activity breaks were more effective than continuous physical activity at decreasing postprandial glycemia and insulinemia in healthy, normal-weight adults.
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This article is published in The American Journal of Clinical Nutrition.The article was published on 2013-08-01 and is currently open access. It has received 355 citations till now.

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Sedentary behaviour and risk of all-cause, cardiovascular and cancer mortality, and incident type 2 diabetes: a systematic review and dose response meta-analysis

TL;DR: Independent of PA, total sitting and TV viewing time are associated with greater risk for several major chronic disease outcomes, and for all-cause and CVD mortality, a threshold of 6–8 h/day of total Sitting and 3–4 h / day of TV viewing was identified, above which the risk is increased.
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Combined Effects of Time Spent in Physical Activity, Sedentary Behaviors and Sleep on Obesity and Cardio-Metabolic Health Markers: A Novel Compositional Data Analysis Approach

TL;DR: Time spent in MVPA is an important target for intervention and preventing transfer of time from LIPA to SB might lessen the negative effects of physical inactivity, so time spent in each of these behaviors are codependent.
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Patterns of sedentary behavior and mortality in U.S. middle-aged and older adults a national cohort study

TL;DR: In this article, the authors examined the association between objectively measured sedentary behavior (its total volume and accrual in prolonged, uninterrupted bouts) and all-cause mortality and found that greater total sedentary time (HR, 1.22 [95% CI, 0.80 to 1.85]; and HR,1.96 [CI, 131 to 2.63] were both associated with a higher risk for all cause mortality.
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Breaking up prolonged sitting with light-intensity walking improves postprandial glycemia, but breaking up sitting with standing does not

TL;DR: This study suggests that interrupting sitting time with frequent brief bouts of light-intensity activity, but not standing, imparts beneficial postprandial responses that may enhance cardiometabolic health.
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Benefits for Type 2 Diabetes of Interrupting Prolonged Sitting With Brief Bouts of Light Walking or Simple Resistance Activities

TL;DR: Interrupting prolonged sitting with brief bouts of light-intensity walking or simple resistance activities or SRA attenuates acute postprandial glucose, insulin, C-peptide, and triglyceride responses in adults with T2D.
References
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Journal ArticleDOI

Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women

TL;DR: To test the hypothesis that very high levels of nonfasting triglycerides predict myocardial infarction, ischemic heart disease, and death, a prospective cohort study of women and men from the general population of Copenhagen, Denmark followed up from baseline (1976-1978) until 2004.
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Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women.

TL;DR: In this cohort of initially healthy women, nonfasting triglyceride levels were associated with incident cardiovascular events, independent of traditional cardiac risk factors, levels of other lipids, and markers of insulin resistance; by contrast, fasting triglycerides showed little independent relationship.
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Breaks in Sedentary Time: Beneficial associations with metabolic risk

TL;DR: Evidence is provided of the importance of avoiding prolonged uninterrupted periods of sedentary (primarily sitting) time and new public health recommendations regarding breaking up sedentary time that are complementary to those for physical activity are suggested.
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Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003–06

TL;DR: These are the first population-representative findings on the deleterious associations of prolonged sedentary time with cardio-metabolic and inflammatory biomarkers and suggest that clinical communications and preventive health messages on reducing and breaking up sedentaryTime may be beneficial for cardiovascular disease risk.
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