Breast cancer mutation in GATA3 zinc finger 1 induces conformational changes leading to the closer binding of ZnFn2 with a wrapping architecture.
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Cites background from "Breast cancer mutation in GATA3 zin..."
...Karn and Emerson suggested that mutations in GATA3 resulted in differential gene expression in ER-positive breast tumors, which affected prognosis [8]....
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References
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"Breast cancer mutation in GATA3 zin..." refers background in this paper
...Cancer is one of the most challenging disease existing in the modern world, causing >9 million annual death (Bray et al., 2018)....
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...Cancer incidences and mortality reported by GLOBOCAN 2018, WHO indicate that lung cancer tops the list, followed by breast cancer, colorectal, prostate, stomach, liver, and others, respectively (Bray et al., 2018; Ferlay et al., 2012)....
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"Breast cancer mutation in GATA3 zin..." refers methods in this paper
...The mutation was carried out manually (Figure 1) at position 294 to mutate Methionine (M) into Lysine (K) by using PyMol software (DeLano, 2002)....
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14,768 citations
"Breast cancer mutation in GATA3 zin..." refers background in this paper
...Breast cancer is a highly complex form of cancer, classified into six subtypes based on the transcriptomic data as – Luminal A; Luminal B; HER2 positive; basal like; claudin-low and normal breast-like (Perou et al., 2000; Sorlie et al., 2001)....
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