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Brief UltraRapid Communication MiR423-5p As a Circulating Biomarker for Heart Failure
Anke J. Tijsen,Esther E. Creemers,Perry D. Moerland,Leon J. De Windt,Allard C. van der Wal,Wouter E. Kok,Yigal M. Pinto +6 more
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In this article, a miRNA array was performed on plasma of 12 healthy controls and 12 heart failure patients and selected 16 miRNAs for a second clinical study in 39 healthy control and 50 cases with reports of dyspnea.Abstract:
Rationale: Aberrant expression profiles of circulating microRNAs (miRNAs) have been described in various diseases and provide high sensitivity and specificity. We explored circulating miRNAs as potential biomarkers in patients with heart failure (HF). Objective: The goal of this study was to determine whether miRNAs allow to distinguish clinical HF not only from healthy controls but also from non-HF forms of dyspnea. Methods and Results: A miRNA array was performed on plasma of 12 healthy controls and 12 HF patients. From this array, we selected 16 miRNAs for a second clinical study in 39 healthy controls and in 50 cases with reports of dyspnea, of whom 30 were diagnosed with HF and 20 were diagnosed with dyspnea attributable to non–HF-related causes. This revealed that miR423-5p was specifically enriched in blood of HF cases and receiver-operator-characteristics (ROC) curve analysis showed miR423-5p to be a diagnostic predictor of HF, with an area under the curve of 0.91 (P<0.001). Five other miRNAs were elevated in HF cases but also slightly increased in non-HF dyspnea cases. Conclusion: We identify 6 miRNAs that are elevated in patients with HF, among which miR423-5p is most strongly related to the clinical diagnosis of HF. These 6 circulating miRNAs provide attractive candidates as putative biomarkers for HF. (Circ Res. 2010;106:1035-1039.)read more
Citations
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Journal ArticleDOI
MicroRNAs in Stress Signaling and Human Disease
Joshua T. Mendell,Eric N. Olson +1 more
TL;DR: Emerging principles of miRNA regulation of stress signaling pathways are reviewed and applied to the authors' understanding of the roles of miRNAs in disease.
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Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes
Anna Zampetaki,Stefan Kiechl,Ignat Drozdov,Peter Willeit,Ursula Mayr,Marianna Prokopi,Agnes Mayr,Siegfried Weger,Friedrich Oberhollenzer,Enzo Bonora,Ajay M. Shah,Johann Willeit,Manuel Mayr +12 more
TL;DR: A plasma miRNA signature for DM is revealed that includes loss of endothelial miR-126, which might explain the impaired peripheral angiogenic signaling in patients with DM.
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Circulating MicroRNAs in Patients With Coronary Artery Disease
Stephan Fichtlscherer,Salvatore De Rosa,Henrik Fox,Thomas Schwietz,Ariane Fischer,Christoph Liebetrau,Michael Weber,Christian W. Hamm,Tino Röxe,Marga Muller-Ardogan,Angelika Bonauer,Andreas M. Zeiher,Stefanie Dimmeler +12 more
TL;DR: Circulating levels of vascular and inflammation-associated microRNAs are significantly downregulated in patients with coronary artery disease.
Journal ArticleDOI
Circulating MicroRNAs: Novel Biomarkers and Extracellular Communicators in Cardiovascular Disease?
TL;DR: The nature of the stability of miRNAs that circulate in the bloodstream are discussed and the available evidence regarding the possible function of these circulating mi RNAs in distant cell-to-cell communication is discussed.
Journal ArticleDOI
Cardiac fibroblast–derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy
Claudia Bang,Sandor Batkai,Seema Dangwal,Shashi Kumar Gupta,Ariana Foinquinos,Angelika Holzmann,Annette Just,Janet Remke,Karina Zimmer,Andre Zeug,Evgeni Ponimaskin,Andreas Schmiedl,Xiaoke Yin,Manuel Mayr,Rashi Halder,Andre Fischer,Stefan Engelhardt,Yuanyuan Wei,Andreas Schober,Jan Fiedler,Thomas Thum +20 more
TL;DR: It is found that cardiac fibroblasts secrete star miRNA-enriched exosomes and fibroblast-derived miR-21* is identified as a paracrine signaling mediator of cardiomyocyte hypertrophy that has potential as a therapeutic target.
References
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Circulating microRNAs as stable blood-based markers for cancer detection
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NT-proBNP testing for diagnosis and short-term prognosis in acute destabilized heart failure : an international pooled analysis of 1256 patients : the International Collaborative of NT-proBNP Study
James L. Januzzi,Roland R.J. van Kimmenade,John G. Lainchbury,Antoni Bayes-Genis,Jordi Ordóñez-Llanos,Miguel Santalo-Bel,Yigal M. Pinto,Mark Richards +7 more
TL;DR: In this multi-centre, international study, NT-proBNP testing was valuable for diagnostic evaluation and short-term prognosis estimation in dyspnoeic subjects with suspected or confirmed acute HF and should establish broader standards for use of the NT- ProBNP in dysPNoeic patients.
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MicroRNAs in the Human Heart A Clue to Fetal Gene Reprogramming in Heart Failure
Thomas Thum,Paolo Galuppo,Christian Wolf,Jan Fiedler,Susanne Kneitz,Linda W. van Laake,Pieter A. Doevendans,Christine L. Mummery,Jürgen Borlak,Axel Haverich,Carina Gross,Stefan Engelhardt,Georg Ertl,Johann Bauersachs +13 more
TL;DR: Evidence is provided that cardiac microRNAs, recently discovered key regulators of gene expression, contribute to the transcriptional changes observed in heart failure as well as changes in gene expression comparable to the failing heart.
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MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets
Eva van Rooij,Eric N. Olson +1 more
TL;DR: Key roles of microRNAs as regulators of the growth, development, function, and stress responsiveness of the heart are revealed, providing glimpses of undiscovered regulatory mechanisms and potential therapeutic targets for the treatment of heart disease.
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