Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation.
Petra Kotzbeck,Antonio Giordano,Eleonora Mondini,Incoronata Murano,Ilenia Severi,Wiebe Venema,Maria Paola Cecchini,Erin E. Kershaw,Giorgio Barbatelli,Guenter Haemmerle,Rudolf Zechner,Saverio Cinti +11 more
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TLDR
The present findings suggest that converted enlarged brown adipocytes are highly prone to death, which, by promoting inflammation in whitened BAT, may contribute to the typical inflammatory state seen in obesity.About:
This article is published in Journal of Lipid Research.The article was published on 2018-03-29 and is currently open access. It has received 144 citations till now. The article focuses on the topics: Brown adipose tissue & Adipose tissue.read more
Citations
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Journal ArticleDOI
Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics
TL;DR: In this paper, the importance of white adipocyte hypertrophy and the interplay between metabolic pathways explains the fine-tuning between the anabolic and catabolic fates of fatty acids and glucose in different physiological states.
OtherDOI
Adipose Organ Development and Remodeling
TL;DR: The plastic properties of this organ could open new therapeutic perspectives in the obesity-related metabolic disease and in breast pathologies.
Journal ArticleDOI
LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
Elena Schmidt,Elena Schmidt,Ines Dhaouadi,Ines Dhaouadi,Isabella Gaziano,Isabella Gaziano,Matteo Oliverio,Matteo Oliverio,Paul Klemm,Paul Klemm,Motoharu Awazawa,Motoharu Awazawa,Gerfried Mitterer,Eduardo Fernandez-Rebollo,Eduardo Fernandez-Rebollo,Marta Pradas-Juni,Marta Pradas-Juni,Marta Pradas-Juni,Wolfgang Wagner,Philipp Hammerschmidt,Philipp Hammerschmidt,Rute Loureiro,Rute Loureiro,Rute Loureiro,Christoph A. Kiefer,Nils R. Hansmeier,Nils R. Hansmeier,Sajjad Khani,Sajjad Khani,Matteo Bergami,Markus Heine,Evgenia Ntini,Peter Frommolt,Peter Zentis,Ulf Andersson Ørom,Jörg Heeren,Matthias Blüher,Martin Bilban,Jan-Wilhelm Kornfeld,Jan-Wilhelm Kornfeld,Jan-Wilhelm Kornfeld +40 more
TL;DR: A maternally expressed, imprinted lncRNA, H19, that increases BAT oxidative metabolism and energy expenditure is identified and it is demonstrated that H19 recruits PEG-inactivating H19-MBD1 complexes and acts as BAT-selective PEG gatekeeper.
Journal ArticleDOI
Of mice and men: The physiological role of adipose triglyceride lipase (ATGL).
TL;DR: This review gives an update on how ATGL is regulated on the transcriptional and post-transcriptional level and how this affects the enzymes' activity in the context of neutral lipid catabolism.
Journal ArticleDOI
The Importance of Breast Adipose Tissue in Breast Cancer
TL;DR: The importance of breast adipose tissue in breast development and its involvement in breast changes happening during pregnancy, lactation and involution is discussed, with an overview on its involved in the various steps of breast cancer development and progression.
References
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Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Obesity is associated with macrophage accumulation in adipose tissue
Stuart P. Weisberg,Daniel McCann,Manisha Desai,Michael Rosenbaum,Rudolph L. Leibel,Anthony W. Ferrante +5 more
TL;DR: Transcript expression in perigonadal adipose tissue from groups of mice in which adiposity varied due to sex, diet, and the obesity-related mutations agouti (Ay) and obese (Lepob) found that the expression of 1,304 transcripts correlated significantly with body mass.
Journal ArticleDOI
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.
Haiyan Xu,Glenn Barnes,Qing Yang,Guo Tan,Daseng Yang,Chieh J. Chou,Jason Sole,Andrew Nichols,Jeffrey S. Ross,Louis A. Tartaglia,Hong Chen +10 more
TL;DR: It is proposed that obesity-related insulin resistance is, at least in part, a chronic inflammatory disease initiated in adipose tissue, and that macrophage-related inflammatory activities may contribute to the pathogenesis of obesity-induced insulin resistance.
Journal ArticleDOI
Brown Adipose Tissue: Function and Physiological Significance
Barbara Cannon,Jan Nedergaard +1 more
TL;DR: The development of brown adipose tissue with its characteristic protein, uncoupling protein-1 (UCP1), was probably determinative for the evolutionary success of mammals, as its thermogenesis enhances neonatal survival and allows for active life even in cold surroundings.
Journal ArticleDOI
Identification and Importance of Brown Adipose Tissue in Adult Humans
AM Cypess,Sanaz Lehman,Gethin Williams,Ilan Tal,Dean Rodman,Allison B. Goldfine,FC Kuo,Edwin L. Palmer,Yu-Hua Tseng,Alessandro Doria,Gerald M. Kolodny,C R Kahn +11 more
TL;DR: Defined regions of functionally active brown adipose tissue are present in adult humans, are more frequent in women than in men, and may be quantified noninvasively with the use of (18)F-FDG PET-CT.