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Journal Article

Burkitt’s Lymphoma: a review of the epidemiology

01 Jan 2001-Kuwait Medical Journal (Kuwait Medical Association)-Vol. 33, pp 293-306
About: This article is published in Kuwait Medical Journal.The article was published on 2001-01-01 and is currently open access. It has received 29 citations till now. The article focuses on the topics: Burkitt's lymphoma.
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Journal ArticleDOI
TL;DR: Adjuvant monoclonal antibody therapy with rituximab shows promise for improved outcomes and reduced toxic effects in the future.

457 citations

Journal ArticleDOI
TL;DR: It is suggested that the true extent of EBV diversity is likely to be greater than is currently recognized and additional studies conducted in carefully selected populations, that are sufficiently powered to provide robust estimates, and that utilize testing approaches that permit full characterization of viral diversity are needed.

194 citations


Cites background from "Burkitt’s Lymphoma: a review of the..."

  • ...In contrast to NPC, the tight link between BL and EBV is only observed in Equatorial Africa, while in other regions only a fraction of BL cases are associated with EBV (Brady et al., 2008;Cardy et al., 2001;Chan et al., 1995;Gutierrez et al., 1992;Klumb et al., 2004;Mbulaiteye et al., 2009;Philip, 1985;Rochford et al., 2005)....

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Journal Article
30 Nov 2008-Oncology
TL;DR: Burkitt lymphoma in adults cannot be treated effectively with the common regimens used for diffuse large B-cell lymphoma such as CHOP-R, so prompt diagnosis and initiation of appropriate therapy with attention to the possibility of tumor lysis syndrome are necessary for optimal results.
Abstract: Burkitt lymphoma is a unique B-cell malignancy with a high proliferation rate and characteristic genetic changes involving the c-myc oncogene. Burkitt lymphoma is common in children but also occurs in adults, where distinction from diffuse large B-cell lymphoma may pose a problem. The development of brief, very intensive chemotherapy regimens has led to a very high cure rate in children with Burkitt lymphoma. The use of these regimens in adults, often in combination with the antibody rituximab (Rituxan), has also made the cure of a majority of adults possible. Burkitt lymphoma in adults cannot be treated effectively with the common regimens used for diffuse large B-cell lymphoma such as CHOP-R (cyclophosphamide, doxorubicin HCl, vincristine [Oncovin], prednisone, rituximab). Prompt diagnosis and initiation of appropriate therapy with attention to the possibility of tumor lysis syndrome are necessary for optimal results.

58 citations

Journal ArticleDOI
TL;DR: Immunohistochemical detection of Latent Membrane Protein 1 (LMP1) expression and Epstein-Barr virus Encoded RNA (EBER) In Situ Hybridization (ISH) procedures have been performed, and EBV has been detected in children and adult patients.
Abstract: The exact worldwide incidence of Burkitt’s lymphoma is not known. There are three distinct clinical variants of Burkitt’s lymphoma, each manifesting differences in epidemiology, clinical presentation, morphology, biology and genetic features: the endemic (African), the sporadic (non-endemic), and the immunodeficiency-associated form. In particular, we reported data regarding Burkitt’s lymphoma incidence in the world and across different European countries. Finally, we described clinic-pathological data of 48 Burkitt’s lymphomas occurred in Italy from 2003 to 2013, in 4 different hospitals, two of which located in east side, and the other ones located in the west-coast. Forty Burkitt’s lymphomas occurs in children (age range 3–12), and 8 were adulthood Burkitt’s lymphomas (age range 18–87). In the pediatric group the Male:Female ratio (M:F) was of 4:1, whereas the group of the adult patients has a M:F of 1:1.67. Immunohistochemical detection of Latent Membrane Protein 1 (LMP1) expression and Epstein-Barr virus Encoded RNA (EBER) In Situ Hybridization (ISH) procedures have been performed. Lymphocyte B monoclonal spread has been demonstrated using a Polymerase Chain Reaction (PCR) based method to amplify Fragment Restriction FR1, FR2 and FR3 immunoglobulin heavy chains DNA fragments. Only 38 cases out of 48 were analyzed for LMP-1 showing various percentage of stained cells in 47.4% of the patients. Considering ISH for EBER detection results: – 1 out 2 (50%) adult analyzed cases was positive, with 50% of stained tumor cells (this patient was a 22 years old female, coming from Napoli); – 15 out 24 (62.5%) children analyzed Burkitt’s lymphomas resulted as positive for EBER; – the overall positivity has been observed in 16/26 Burkitt’s lymphomas (61.53%). – Finally, EBV has been detected in children and adult patients, one of them with deregulation of the oncogene c-MYC by chromosomal translocation.

44 citations


Cites background from "Burkitt’s Lymphoma: a review of the..."

  • ...The geographic distribution of Burkitt’s lymphoma identifies high, intermediate and low-risk areas [30]....

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Book ChapterDOI
TL;DR: The putative role of haptoglobin polymorphism in parasitic, bacterial, and viral infections is examined and the effects are not always predictable due to the multifunctional character of the plasma protein.
Abstract: The haptoglobin gene is highly polymorphic in humans with strong evidence of functionally distinct biochemical phenotypes. In all human populations, three major haptoglobin phenotypes Hp 1-1, Hp 2-1, and Hp 2-2 are present, but additional phenotypes have been identified. Haptoglobin polymorphism has important biological and clinical significance. In this review, we examine the putative role of haptoglobin polymorphism in parasitic, bacterial, and viral infections. Despite many striking effects of haptoglobin polymorphism in infectious conditions, the effects of haptoglobin genetic variation upon infections are not always predictable due to the multifunctional character of the plasma protein (e.g., antibody-like properties, immunomodulation, iron metabolism). More studies on the interplay of haptoglobin polymorphism, vaccination, and susceptibility or resistance to common infections seem warranted.

38 citations