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Caffeine and Exercise: What Next?

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TLDR
It is proposed that a better understanding of the wider, non-direct effects of caffeine on exercise, such as how it modifies sleep, anxiety, and post-exercise recovery, will ensure athletes can maximize the performance benefits of caffeine supplementation during both training and competition.
Abstract
Caffeine is a widely utilized performance-enhancing supplement used by athletes and non-athletes alike. In recent years, a number of meta-analyses have demonstrated that caffeine’s ergogenic effects on exercise performance are well-established and well-replicated, appearing consistent across a broad range of exercise modalities. As such, it is clear that caffeine is an ergogenic aid—but can we further explore the context of this ergogenic aid in order to better inform practice? We propose that future research should aim to better understand the nuances of caffeine use within sport and exercise. Here, we propose a number of areas for exploration within future caffeine research. These include an understanding of the effects of training status, habitual caffeine use, time of day, age, and sex on caffeine ergogenicity, as well as further insight into the modifying effects of genotype. We also propose that a better understanding of the wider, non-direct effects of caffeine on exercise, such as how it modifies sleep, anxiety, and post-exercise recovery, will ensure athletes can maximize the performance benefits of caffeine supplementation during both training and competition. Whilst not exhaustive, we hope that the questions provided within this manuscript will prompt researchers to explore areas with the potential to have a large impact on caffeine use in the future.

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Journal ArticleDOI

Effect of Caffeine Supplementation on Sports Performance Based on Differences Between Sexes: A Systematic Review.

TL;DR: Caffeine supplementation produced a similar ergogenic benefit for aerobic performance and the fatigue index in men and women athletes, Nevertheless, the effects of caffeine to produce more power, total weight lifted and to improve sprint performance with respect to a placebo was higher in men than women athletes despite the same dose of caffeine being administered.
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The Role of Genetics in Moderating the Inter-Individual Differences in the Ergogenicity of Caffeine.

TL;DR: Caffeine use is widespread among athletes following its removal from the World Anti-Doping Agency banned list, with approximately 75% of competitive athletes using caffeine and the role that genetics has in these differences is discussed.
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Caffeine use in a Super Rugby game and its relationship to post-game sleep.

TL;DR: Caffeine consumption before a Super Rugby game markedly increases post-game saliva caffeine levels, which may contribute to the observed 3.5 h delay in time at sleep onset and the 1.
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Establishing a relationship between the effect of caffeine and duration of endurance athletic time trial events: A systematic review and meta-analysis.

TL;DR: This study is the first to report on the statistical finding that the effect size of caffeine increases along with the increasing duration of the time trial event.
References
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Journal ArticleDOI

Caffeine and exercise: metabolism, endurance and performance

TL;DR: The limited information available suggests that caffeine non-users and users respond similarly and that withdrawal from caffeine may not be important, and caffeine may act synergistically with other drugs including ephedrine and anti-inflammatory agents.
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Functional significance of a C-->A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine

TL;DR: The A/A genotype may either be a direct cause of increased CYP1A2 activity, or be genetically linked to polymorphisms conferring high inducibility, and further studies are needed to define the role of this polymorphism on the pharmacokinetics of drugs metabolised by CYP 1A2 and in the activation of carcinogens.
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Caffeine (1, 3, 7-trimethylxanthine) in Foods: A Comprehensive Review on Consumption, Functionality, Safety, and Regulatory Matters

TL;DR: Performance benefits attributed to caffeine include physical endurance, reduction of fatigue, and enhancing mental alertness and concentration, however, the caloric contribution of caffeine-sweetened beverages needs to be considered in the overall energy balance.
Journal ArticleDOI

Validity, Reliability and Sensitivity of Measures of Sporting Performance

TL;DR: A sensitive protocol is one that is able to detect small, but important, changes in performance, and research has shown that time-to-exhaustion protocols are more reliable as they have been shown to have a CV of <5%.
Journal ArticleDOI

Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training

TL;DR: Even in the most adverse circumstances, moderate doses of caffeine can improve cognitive function, including vigilance, learning, memory, and mood state, and a dose of 200 mg appears to be optimal under such conditions.
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