Journal ArticleDOI
Calcitonin gene-related peptide acts within the central nervous system to inhibit gastric acid secretion
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TLDR
It is indicated that CGRP acts within the central nervous system to potently decrease gastric acid secretion by mechanism(s) not dependent on intact sympathetic nervous function.Citations
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Neuroanatomical Localization, Pharmacological Characterization and Functions of CGRP, Related Peptides and Their Receptors
TL;DR: Findings on the anatomical distributions of CGRP mRNA, C GRP-like immunoreactivity and receptors in the central nervous system, as well as the potential physiological roles for CGRp are discussed.
Journal ArticleDOI
Calcitonin gene-related peptide: Detailed immunohistochemical distribution in the central nervous system
TL;DR: It can only be conjectured that CGRP has a neuroregulatory action on a variety of functions throughout the brain and spinal cord.
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Calcitonin gene-related peptide coexists with substance P in capsaicin sensitive neurons and sensory ganglia of the rat.
TL;DR: It is suggested that CGRP, like substance P, may have a neuromodulatory role on nociception and peripheral cardiovascular reflexes.
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Characterization of the peptidergic afferent innervation of the stomach in the rat, mouse and guinea-pig
T. Grhkn,Graham J. Dockray +1 more
TL;DR: Results provide direct evidence that calcitonin gene-related peptide is a marker for a major subset of visceral primary afferent neurons and suggest that this population of spinal afferents makes a major contribution to the total gastric content of calcitonIn gene- related peptide.
Journal ArticleDOI
Functional, bioactive and antioxidative properties of hydrolysates obtained from cod (Gadus morhua) backbones
Rasa Šližytė,Revilija Mozuraitytė,Oscar Martínez-Alvarez,Eva Falch,Martine Fouchereau-Peron,Turid Rustad +5 more
TL;DR: In this paper, the authors evaluated how storage and preparation of cod (Gadus morhua) backbones influence the yield, functionality, bioactivity (CGRP and gastrin/CCK related molecules) and antioxidative properties of fish protein hydrolysates.
References
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Journal ArticleDOI
Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing
Michael G. Rosenfeld,Jean-Jacques Mermod,Susan G. Amara,Larry W. Swanson,Paul E. Sawchenko,Jean Rivier,Wylie Vale,Ronald M. Evans +7 more
TL;DR: The approach described here permits the application of recombinant DNA technology to analyses of complex neurobiological systems in the absence of prior structural or biological information.
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Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products
TL;DR: A model in which developmental regulation of RNA processing is used to increase the diversity of neuroendocrine gene expression is proposed.
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Stimulation of noradrenergic sympathetic outflow by calcitonin gene-related peptide.
Laurel A. Fisher,Don O. Kikkawa,Jean Rivier,Susan G. Amara,Ronald M. Evans,Michael G. Rosenfeld,Wylie Vale,Marvin R. Brown +7 more
TL;DR: It is reported here that CGRP acts in the central nervous system to stimulate selectively noradrenergic sympathetic outflow and is identified immunocytochemically throughout the central and peripheral nervous systems.
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A quantitative method for measuring spontaneous gastric secretion in the rat.
TL;DR: The present investigation is prompted to offer a standard technic for the study of gastric secretion in the rat that might permit a comparison of results obtained with this preparation in different laboratories-a comparison not possible at the present time.
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Release of the predicted calcitonin gene-related peptide from cultured rat trigeminal ganglion cells
TL;DR: It is reported here that immunoreactive CGRP is spontaneously released by cultured trigeminal ganglion cells and that secretion is stimulated by incubation in high potassium medium in a calcium-dependent fashion.