Journal ArticleDOI
Camptocormia (bent spine) in patients with Parkinson's disease--characterization and possible pathogenesis of an unusual phenomenon.
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TLDR
Eight patients with presumed idiopathic Parkinson's disease who developed camptocormia are described for the first time, and this impressive abnormal posture emerged 4–14 years from disease onset, and in some patients stooped posture was the prominent symptom at diagnosis.Abstract:
Camptocormia is characterized by severe forward flexion of the thoracolumbar spine which increases while walking and disappears in the recumbent position. We describe for the first time eight patients with presumed idiopathic Parkinson's disease (mean age 66+/-5 yrs; mean symptom duration 13.1+/-5.1 yrs) who developed camptocormia. This impressive abnormal posture emerged 4-14 years from disease onset, and in some patients stooped posture was the prominent symptom at diagnosis. There was no clear correlation between camptocormia and levodopa treatment. In some patients the camptocormic posture improved, and in others it was unchanged or even aggravated following levodopa administration. Three patients reported worsening of this symptom during "off" periods and also with fatigue. The pathogenesis of this phenomenon is unknown but might represent either a rare type of dystonia or an extreme form of rigidity.read more
Citations
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Journal ArticleDOI
Parkinson’s disease: clinical features and diagnosis
TL;DR: A thorough understanding of the broad spectrum of clinical manifestations of PD is essential to the proper diagnosis of the disease and genetic mutations or variants, neuroimaging abnormalities and other tests are potential biomarkers that may improve diagnosis and allow the identification of persons at risk.
Journal ArticleDOI
Postural deformities in Parkinson's disease
Karen M. Doherty,Bart P.C. van de Warrenburg,Maria Cecilia Peralta,Laura Silveira-Moriyama,Jean-Philippe Azulay,Oscar S. Gershanik,Bastiaan R. Bloem +6 more
TL;DR: Improved understanding of the mechanisms underlying postural deformities in PD might ultimately lead to more effective management strategies for these disabling and drug-refractory complications.
Pain in Parkinson's disease.
TL;DR: A framework for diagnosing and treating painful PD is described in this review, together with recent insignts into the neurophysiological mechanisms and substrates of pain in PD.
Journal ArticleDOI
Camptocormia: Pathogenesis, classification, and response to therapy
Shaheda N. Azher,Joseph Jankovic +1 more
TL;DR: Etiologic classification of camptocormia is proposed and it is concluded that this heterogeneous disorder has multiple etiologies and variable response to systemic and local therapies.
Journal ArticleDOI
Pain in Parkinson's disease.
TL;DR: Parkinson's disease is characterized primarily as a neurodegenerative disorder that leads to disabling motor and cognitive impairment as mentioned in this paper, although the prevalence of pain in PD is approximately 40%.
References
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Book ChapterDOI
Fluctuations of disability in Parkinson's disease – clinical aspects
TL;DR: This chapter discusses that Parkinson's disease, although in most respects a chronic, progressive disorder, can also be seen as a paroxysmal condition.
Journal ArticleDOI
Corticostriatal transformations in the primate somatosensory system. Projections from physiologically mapped body-part representations.
TL;DR: These experiments demonstrate that the somatosensory representations of the body are reorganized as they are projected from SI to the somatoensory sector of the primate putamen, suggesting that the striatal representation of theBody may be functionally distinct from that of each area of SI.
Journal ArticleDOI
Two input systems for body representations in the primate striatal matrix: experimental evidence in the squirrel monkey
TL;DR: It is found that inputs from regions of ipsilateral MI and SI that represented the same body parts sent projections to the same matrisomes of the ipsilaterally putamen, an arrangement reminiscent of the alternating ocular dominance columns in visual cortex.
Journal ArticleDOI
Is camptocormia a primary muscular disease
TL;DR: In patients with camptocormia, computed tomographic scans and magnetic resonance imaging showed heterogeneous appearance of the spinal muscles with areas of low density, distinct from those of patients with interapophyseal osteoarthritis and similar to the features described in primary muscular dystrophies.
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Camptocormia: Pathogenesis, classification, and response to therapy
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