Can Ceftazidime-Avibactam and Aztreonam Overcome β-Lactam Resistance Conferred by Metallo-β-Lactamases in Enterobacteriaceae?
Citations
480 citations
336 citations
271 citations
211 citations
155 citations
References
1,541 citations
457 citations
414 citations
"Can Ceftazidime-Avibactam and Aztre..." refers background in this paper
...The monobactam antibiotic aztreonam (ATM) remains stable against MBLs but is not a therapeutic option in many cases because it is inactivated by ESBLs, KPCs, and other cephalosporinases frequently found in the background of MBL-producing bacteria (2, 3)....
[...]
...In response, the “antibiotic pipeline” has delivered an important -lactam– lactamase inhibitor combination, ceftazidime-avibactam (CAZ-AVI) (2)....
[...]
341 citations
"Can Ceftazidime-Avibactam and Aztre..." refers background in this paper
...Additionally, MBLs are a worldwide problem, with outbreaks reported in the United States in numbers that were previously unanticipated (6, 7)....
[...]
255 citations
"Can Ceftazidime-Avibactam and Aztre..." refers background in this paper
...An unexpected benefit from using CAZ and ATM may arise by the simultaneous inhibition of multiple penicillin-binding proteins (PBPs)....
[...]
...For CAZ and ATM, zones of inhibition were interpreted according to the Clinical and Laboratory Standards Institute (CLSI) guidelines (9)....
[...]
...possess class C enzymes and possibly some class A ESBLs, we reasoned that AVI would prevent the hydrolysis of CAZ and ATM (10)....
[...]
...AVI is a very potent -lactamase inhibitor of class A and C enzymes, and since most strains of Enterobacter spp. possess class C enzymes and possibly some class A ESBLs, we reasoned that AVI would prevent the hydrolysis of CAZ and ATM (10)....
[...]