Journal ArticleDOI
Cancer cell membrane-coated biomimetic platform for tumor targeted photodynamic therapy and hypoxia-amplified bioreductive therapy.
Shi-Ying Li,Hong Cheng,Wen-Xiu Qiu,Lu Zhang,Shuang-Shuang Wan,Jing-Yue Zeng,Xian-Zheng Zhang +6 more
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TLDR
An overwhelming superiority of utilizing this bioinspired strategy for tumor targeted PDT and hypoxia-activated bioreductive therapy is indicated, which provided a new insight for precise and effective tumor treatment.About:
This article is published in Biomaterials.The article was published on 2017-10-01. It has received 193 citations till now. The article focuses on the topics: Tumor microenvironment & Primary tumor.read more
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Cell Membrane Coating Nanotechnology
TL;DR: There is still significant room for development, as researchers continue to refine existing workflows while finding new and exciting applications that can take advantage of this developing technology, cell‐membrane‐coating nanotechnology.
Journal ArticleDOI
Erythrocyte Membrane Cloaked Metal-Organic Framework Nanoparticle as Biomimetic Nanoreactor for Starvation-Activated Colon Cancer Therapy.
TL;DR: The in vitro and in vivo outcomes indicate the fabricated biomimetic nanoreactor exhibits a strong synergistic cascade effect for colon cancer therapy in an accurate and facile manner.
Journal ArticleDOI
Biomimetic Metal-Organic Framework Nanoparticles for Cooperative Combination of Antiangiogenesis and Photodynamic Therapy for Enhanced Efficacy.
Huan Min,Jing Wang,Jing Wang,Yingqiu Qi,Yingqiu Qi,Yinlong Zhang,Yinlong Zhang,Xuexiang Han,Xuexiang Han,Ying Xu,Ying Xu,Junchao Xu,Junchao Xu,Yao Li,Long Chen,Long Chen,Keman Cheng,Guangna Liu,Na Yang,Na Yang,Yiye Li,Yiye Li,Guangjun Nie,Guangjun Nie +23 more
TL;DR: A biomimic, multifunctional nanoparticle‐based PDT agent, combining a tumor‐targeted photosensitizer with GSH scavenging and antiangiogenesis therapy, is developed that significantly improves their tumor inhibition efficiency.
Journal ArticleDOI
Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics.
TL;DR: This review has summarized the general strategies of developing stimuli-responsive nanocarriers and recent advances, presented their applications in drug delivery, tumor imaging, therapy and theranostics, illustrated the progress of clinical translation and made prospects.
Journal ArticleDOI
Recent progress in the development of near-infrared organic photothermal and photodynamic nanotherapeutics.
TL;DR: This review summarizes the synthesis and application of NIR-absorbing organic nanoparticles as phototherapeutic nanoagents for cancer phototherapy and the present challenges and potential of imaging guided PTT/PDT combined therapy.
References
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Journal ArticleDOI
Genes that mediate breast cancer metastasis to lung
Andy J. Minn,Gaorav P. Gupta,Peter M. Siegel,Peter M. Siegel,Paula D. Bos,Weiping Shu,Dilip Giri,Dilip Giri,Agnes Viale,Adam B. Olshen,William L. Gerald,Joan Massagué +11 more
TL;DR: A set of genes are identified that marks and mediates breast cancer metastasis to the lungs and serve dual functions, providing growth advantages both in the primary tumour and in the lung microenvironment.
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Cancer Nanotechnology: The impact of passive and active targeting in the era of modern cancer biology
TL;DR: The fundamental concepts of enhanced permeability and retention effect (EPR) are revisited and the mechanisms proposed to enhance preferential "retention" in the tumor, whether using active targeting of nanoparticles, binding of drugs to their tumoral targets or the presence of tumor associated macrophages are explored.
Journal ArticleDOI
Photodynamic therapy and anti-tumour immunity
TL;DR: Photodynamic therapy uses non-toxic photosensitizers and harmless visible light in combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant cells by apoptosis and/or necrosis, shut down the tumour microvasculature and stimulate the host immune system.
Journal ArticleDOI
Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform
TL;DR: A top-down biomimetic approach in particle functionalization is reported by coating biodegradable polymeric nanoparticles with natural erythrocyte membranes, including both membrane lipids and associated membrane proteins for long-circulating cargo delivery.
Journal ArticleDOI
The role of porphyrin chemistry in tumor imaging and photodynamic therapy
TL;DR: This critical review is focused on the basic concept of PDT, advantages of long-wavelength absorbing photosensitizers (PS), a brief discussion on recent advances in developing PDT agents, and the various synthetic strategies designed at the Roswell Park Cancer Institute, Buffalo.
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