Cancer-related inflammation.
Citations
51,099 citations
Cites background from "Cancer-related inflammation."
...…at the margins of tumors, tissue invasion, and to support themetastatic dissemination and seeding of cancer cells (Coffelt et al., 2010; Egeblad et al., 2010; Qian and Pollard, 2010; Mantovani, 2010; Joyce and Pollard, 2009; Mantovani et al., 2008; Murdoch et al., 2008; DePalma et al., 2007)....
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...Consistent with their expression of these diverse effectors, tumor-infiltrating inflammatory cells have been shown to induce and help sustain tumor angiogenesis, to stimulate cancer cell proliferation, to facilitate, via their presence at the margins of tumors, tissue invasion, and to support themetastatic dissemination and seeding of cancer cells (Coffelt et al., 2010; Egeblad et al., 2010; Qian and Pollard, 2010; Mantovani, 2010; Joyce and Pollard, 2009; Mantovani et al., 2008; Murdoch et al., 2008; DePalma et al., 2007)....
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8,664 citations
Cites background from "Cancer-related inflammation."
...A number of oncoproteins (Ras, Myc, RET) can activate signaling pathways that drive production of proinflammatory cytokines and chemokines (IL-6, IL-8, IL-1b, CCL2, CCL20) (Mantovani et al., 2008)....
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...TAMs are one of the most important players in the inflammation and cancer arena and an important source of cytokines (Mantovani et al., 2008)....
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...Several proinflammatory cytokines that are elevated in the circulation of cancer patients upregulate expression of adhesion molecules on the endothelium or in target organs and thereby increase the probability of metastatic cell attachment (Mantovani et al., 2008)....
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...Most, if not all, solid malignancies trigger an intrinsic inflammatory response that builds up a protumorigenic microenvironment (Mantovani et al., 2008)....
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...A role for inflammation in tumorigenesis is now generally accepted, and it has become evident that an inflammatory microenvironment is an essential component of all tumors, including some in which a direct causal relationship with inflammation is not yet proven (Mantovani et al., 2008)....
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4,721 citations
Cites background from "Cancer-related inflammation."
...Cancer Cancer-related inflammation is characterized by the recruitment of cells of the monocyte-macrophage lineage to tumor tissues (2, 82, 83), which also condition the premetastatic niche, to favor secondary localization of cancer....
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4,287 citations
4,109 citations
References
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"Cancer-related inflammation." refers background in this paper
...jpg" NDATA ITEM> ]> Links between cancer and inflammation were first made in the nineteenth century, on the basis of observations that tumours often arose at sites of chronic inflammation and that inflammatory cells were present in biopsied samples from tumour...
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5,132 citations
4,728 citations
"Cancer-related inflammation." refers background in this paper
...TAMs and related cell types in mouse and human tumours generally have an M2 phenotype, which is oriented towards promoting tumour growth, remodelling tissues, promoting angiogenesis and suppressing adaptive immunity&hairsp...
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3,157 citations
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LPS (lipopolysaccharide) is a molecule that can induce inflammation and is associated with cancer-related inflammation.