Cannabinoid receptor localization in brain
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Cites background from "Cannabinoid receptor localization i..."
...A major initial site of THC binding is the cannabinoid-1 receptor which is widely distributed throughout the brain, but it is particularly concentrated in the extrapyramidal motor system of the rat (Herkenham et al. 1990)....
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Cites background from "Cannabinoid receptor localization i..."
...For 9-THC, careful purification led to a ( )-enantiomer with activity less than 1% of the ( )-enantiomer (Herkenham et al., 1990; Matsuda et al., 1990; Felder et al., 1992; Pertwee, 1997)....
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...Detailed autoradiographic studies have been conducted in several species, including human, monkey, and rat (Herkenham et al., 1990, 1991; Glass et al., 1997)....
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...This suggests that the cellular milieu may be a factor in this CB1 receptor signal transduction pathway....
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...…nonclassical cannabinoids with chiral centers exhibit significant stereoselectivity, those compounds with the same absolute stereochemistry as ( )- 9-THC at 6a and 10a (6aR,10aR) exhibiting the greater pharmacological activity (Little et al., 1988; Herkenham et al., 1990; Melvin et al., 1993)....
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...4), which also displays signs of high affinity and high relative intrinsic activity, at least for CB1 receptors (Howlett et al., 1988; Little et al., 1988; Herkenham et al., 1990; Gérard et al., 1991; Griffin et al., 1998)....
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