Cannabinoids in treatment-resistant epilepsy: A review.
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Cites background from "Cannabinoids in treatment-resistant..."
...It is unclear whether the mechanism underlying this interaction is pharmacokinetic or pharmacodynamic in nature.(87)...
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...A number of such products are accessible in many countries and states under widely different legal and regulatory scenarios.(87,96)...
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165 citations
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References
4,326 citations
"Cannabinoids in treatment-resistant..." refers background in this paper
...Notwithstanding the new therapeutic measures, it remains unclear if the frequency of TRE cases has been reduced during the past two decades [4]....
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3,017 citations
"Cannabinoids in treatment-resistant..." refers background in this paper
...Treatment-resistant epilepsy (TRE) arises from a failure to achieve sustained seizure remission after trials of at least two, appropriately selected antiepileptic drug (AED) regimens that are tolerated at therapeutic dosages [1]....
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2,069 citations
"Cannabinoids in treatment-resistant..." refers background in this paper
...Adverse effects (AEs) of THC in adolescents and adults include cognitive impairment and chronic psychiatric disturbances [46]....
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766 citations
"Cannabinoids in treatment-resistant..." refers background in this paper
...CBD has had documented anticonvulsant effects in multiple pre-clinical animal models [43,48]....
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702 citations
"Cannabinoids in treatment-resistant..." refers background in this paper
...[31] Purified oral 100 mg/ml CBD extract Prospective open label trial in children and young adults with severe childhood onset epilepsy for 12 weeks 214 137 (64%) in efficacy (12 weeks): 36....
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