Cannabis Use and Mental Illness: Understanding Circuit Dysfunction Through Preclinical Models.
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TLDR
In this paper, the authors provide an updated perspective on the preclinical evidence of shared neurobiological mechanisms underpinning the dual diagnosis of cannabis use disorder and a serious mental illness, and propose a consolidated neural circuit-based understanding of the pre-clinical evidence to generate new hypotheses and identify novel therapeutic targets.Abstract:
Patients with a serious mental illness often use cannabis at higher rates than the general population and are also often diagnosed with cannabis use disorder. Clinical studies reveal a strong association between the psychoactive effects of cannabis and the symptoms of serious mental illnesses. Although some studies purport that cannabis may treat mental illnesses, others have highlighted the negative consequences of use for patients with a mental illness and for otherwise healthy users. As epidemiological and clinical studies are unable to directly infer causality or examine neurobiology through circuit manipulation, preclinical animal models remain a valuable resource for examining the causal effects of cannabis. This is especially true considering the diversity of constituents in the cannabis plant contributing to its effects. In this mini-review, we provide an updated perspective on the preclinical evidence of shared neurobiological mechanisms underpinning the dual diagnosis of cannabis use disorder and a serious mental illness. We present studies of cannabinoid exposure in otherwise healthy rodents, as well as rodent models of schizophrenia, depression, and bipolar disorder, and the resulting impact on electrophysiological indices of neural circuit activity. We propose a consolidated neural circuit-based understanding of the preclinical evidence to generate new hypotheses and identify novel therapeutic targets.read more
Citations
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CB1 receptor antagonist AM4113 reverts the effects of cannabidiol on cue and stress-induced reinstatement of cocaine-seeking behaviour in mice
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CB1 receptor antagonist AM4113 reverts the effects of cannabidiol on cue and stress-induced reinstatement of cocaine-seeking behaviour in mice
Olga Valverde,Miguel Luján,Laia Alegre-Zurano,Ana Martín-Sánchez,Lídia Cantacorps,Olga Valverde +5 more
TL;DR: In this paper, the effects and mechanisms of action of cannabidiol in rodent operant models of extinction-based abstinence and drug-seeking relapse were investigated, and the results reveal a series of complex CB1-related changes with a varying impact on the reinstatement of cocaine-seeking behavior that could limit its therapeutic applications.
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Down and High: Reflections Regarding Depression and Cannabis.
TL;DR: A wide-ranging review of the existing literature to examine the influence of cannabis on psychiatric conditions, including mood disorders, is presented in this article. But, there is insufficient data to determine the impact of cannabis use on cognition in individuals with major depression disorder.
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Cannabis Vapour Exposure Alters Neural Circuit Oscillatory Activity In A Neurodevelopmental Model Of Schizophrenia: Exploring The Differential Impact Of Cannabis Constituents
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