Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging
Citations
2,514 citations
Cites background from "Canonical Nlrp3 Inflammasome Links ..."
...In a mouse model, reduction in the Nlrp3 inflammasome-dependent proinflammatory cascade attenuated age-related degenerative changes across multiple organs (39)....
[...]
1,798 citations
1,428 citations
1,223 citations
1,205 citations
References
10,968 citations
"Canonical Nlrp3 Inflammasome Links ..." refers background in this paper
..., 2001) and deposited in NCBI’s Gene Expression Omnibus (Edgar et al., 2002)....
[...]
4,504 citations
"Canonical Nlrp3 Inflammasome Links ..." refers background in this paper
...…activation has been implicated in chronic diseases such as Alzheimer’s diseases (Heneka et al., 2013), diabetes (Masters et al., 2010; Vandanmagsar et al., 2011; Wen et al., 2011; Youm et al., 2011), athero- Cell sclerosis (Duewell et al., 2010), arthritis, and gout (Martinon et al., 2006)....
[...]
..., 2012), uric acid (Martinon et al., 2006), ATP (Mariathasan et al....
[...]
...…by nonmicrobial origin DAMPs such as lipotoxic fatty acids (Wen et al., 2011), ceramides (Vandanmagsar et al., 2011, Youm et al., 2012), free cholesterol (Duewell et al., 2010; Youm et al., 2012), uric acid (Martinon et al., 2006), ATP (Mariathasan et al., 2006), and ROS (Strowig et al., 2012)....
[...]
4,030 citations
"Canonical Nlrp3 Inflammasome Links ..." refers methods in this paper
...Microarray experiments were designed to comply with MIAME guidelines (Brazma et al., 2001) and deposited in NCBI’s Gene Expression Omnibus (Edgar et al....
[...]
3,763 citations
"Canonical Nlrp3 Inflammasome Links ..." refers background in this paper
...Third, the ‘‘inflammaging theory’’ posits that ‘‘aging either physiologically or pathologically can be driven by the proinflammatory cytokines and substances produced by the innate immune system’’ (Franceschi et al., 2000; Goto., 2008)....
[...]
3,032 citations
"Canonical Nlrp3 Inflammasome Links ..." refers background in this paper
...Depending on the disease model, several redundant upstream mechanisms control the processing and secretion of mature IL-1b; these include neutrophil-derived serine proteinase 3 and granzyme A (Dinarello, 2009)....
[...]
...The Nlrp3 inflammasome is unique among innate immune sensors, as it can be activated in response to a diverse array of endogenousmetabolic ‘‘danger signals’’ to induce sterile inflammation in absence of overt infection (Dinarello, 2009; Martinon et al., 2009; Strowig et al., 2012)....
[...]
...IL-1 Partakes in Regulating Age-Related CNS Inflammation and Functional Decline IL-1 signaling downstream of Nlrp3 inflammasome activation is hypothesized to be a major mechanism that controls ‘‘sterile’’ inflammation in CNS and in several age-related chronic diseases including dementia (Dinarello, 2009; Martinon et al., 2009; Strowig et al., 2012)....
[...]
...Cell ingly, despite an important role of IL-1 in osteoarthritis (Dinarello, 2009), during the process of healthy aging, bone loss was dependent on Nlrp3 but independent of downstream IL-1 signaling....
[...]
...Clinically, aging is associated with increases in IL-18, IL-1 receptor antagonist (IL-1RA), and IL-6, while circulating IL-1b levels are undetectable (Ferrucci et al., 2005; Franceschi et al., 2007; Dinarello, 2009)....
[...]