Carbon monoxide-aggravated atherosclerosis in the squirrel monkey.
TL;DR: This work proposes several mechanisms by which carbon monoxide could have aggravated the cholesterol-induced coronary artery lesions and found that in the CO-treated monkeys there was more intimal lipid in each atherosclerotic coronary artery rather than more coronary arteries with intimal cholesterol, as compared with the control group.
About: This article is published in Experimental and Molecular Pathology.The article was published on 1970-08-01. It has received 69 citations till now. The article focuses on the topics: Coronary arteries & Squirrel monkey.
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TL;DR: The physiologic and biochemical bases of carbon monoxide effects in pregnant women, fetuses, and newborn infants and their clinical implications are reviewed.
448 citations
325 citations
TL;DR: There was no evidence that former cigarette smokers, with the exception of those who switched to cigars or pipes or had quit less than one year, had lower HDL levels, and cigar or pipe smokers who had never smoked cigarettes had alcohol- and skinfold-adjusted HDL cholesterol comparable to the non-smoker.
314 citations
TL;DR: The present study supports the concept that tobacco smoking is harmful to the vascular endothelium and contributes to an understanding of the mechanism through which vascular injury is provoked in heavy smokers.
Abstract: The umbilical artery was chosen as a possible model for evaluating the vascular injury provoked by tobacco smoking in humans. Cords from newborn children delivered by 15 nonsmoking and 13 smoking mothers were studied in the transmission and the scanning electron microscope. Pronounced intimal changes were seen in the arteries from smoking mothers; the most important findings were degenerative changes of the endothelium such as swelling, blebbing, contraction, and subsequent opening of the endothelial junctions with formation of subendothelial edema. Other observations included dilation of the endoplasmic reticulum in the endothelium and reparative changes such as a considerable widening of the basement membrane. Since similar changes can be induced in arteries of animals by exposure to carbon monoxide or perfusion with nicotine, we conclude that the present study supports the concept that tobacco smoking is harmful to the vascular endothelium. This study also contributes to an understanding of the mechanism through which vascular injury is provoked in heavy smokers.
179 citations
TL;DR: Considering the ubiquitous repercussions of this menace, vascular surgeons should play an active role in motivating their patients to quit smoking.
171 citations
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01 Jan 1955
TL;DR: Nucleic Acid is a complex biomolecule that stores genetic information in the form of a code that is necessary for life.
Abstract: Nucleic Acids are another important type of organic compound that is necessary for life. A nucleic acid is a complex biomolecule that stores genetic information in the form of a code. Nucleic acids are so named because they arise from the nucleus of the cell. The nucleus is often referred to as the “control center” of the cell because the nucleic acids within contain the coded instruction for all of the cell’s (and therefore the organism’s) activities.
2,080 citations
TL;DR: The underlying biochemical and physiological mechanisms are discussed and it is suggested that the differences observed in the two groups of animals may be explained by tissue hypoxia due to a carbon monoxide-induced displacement of the oxygen dissociation curve to the left, in combination with a decreased activity of certain enzymes inhibited bycarbon monoxide.
177 citations
143 citations
137 citations