Carcinoma of the penis: a clinicopathologic study.
About: This article is published in The Journal of Urology.The article was published on 1970-08-01. It has received 126 citations till now. The article focuses on the topics: Penis.
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TL;DR: Preliminary bilateral SLN biopsy is recommended to be followed by inguinofemoroiliac dissection when biopsy of the SLN is positive for metastatic disease, and no further sugical therapy is immediately indicated.
Abstract: One hundred cases were studied in detail using lymphangiograms (LAG), anatomic dissections, and/or microscopic evaluation. LAG performed via the dorsal lymphatics of the penis demonstrate the existence of specific lymph node center, the so-called sentinel lymph node (SLN). This appears to be the primary site of metastases from penile carcinoma. The SLN is visualized radiographically, on the antero-posterior view, at the junction of the femoral head and the ascending ramus of the pubis. Anatomically, the SLN is part of the lymphatic system around the superficial epigastric vein. Forty-six SLN biopsies were performed with 15 positive for metastatic disease. In these 15 patients, an inguinofemoroiliac dissection was performed; in 12 cases there was no involvement of other lymph nodes. Lymphatic channels draining into the iliac lymph nodes without first draining into the sentinel lymph node were never demonstrated, nor were the inguinal-femoral lymph nodes involved in the absence of SLN involvement. On this bases, we recommend preliminary bilateral SLN biopsy to be followed by inguinofemoroiliac dissection when biopsy of the SLN biopsy to be followed by inguinofemoroiliac dissection when biopsy of the SLN is positive. When biopsy of the SLN is negative for metastatic disease, no further surgical therapy is immediately indicated. With negative SLN, 5-year survival was 90%. When SLN alone was involved, 5-year survival was 70%. Five-year survival was 50% with both SLN and other inguinal nodes involved. When iliac metastases were also present, 3-year survival was 20%.
1,728 citations
TL;DR: The view that common warts (verrucae vulgares, juvenile warts, and genital warts are caused by the same virus and that differences in appearance are the result of variations in location and host reactivity has been shared by dermatologists for several decades.
Abstract: The view that common warts (verrucae vulgares), juvenile warts (verrucae planae), and genital warts (condylomata acuminata) are caused by the same virus and that differences in appearance are the result of variations in location and host reactivity has been shared by dermatologists for several decades (Frey, 1924; Waelsch and Habermann, 1924; Young, 1964; Rowson and Mahy, 1967; Nasemann, 1974; Lever and Schaumburg-Lever, 1975). This has probably reduced the interest in specific types of human papillomas.
611 citations
TL;DR: Surgical debulking combined with reconstruction techniques allowed for improved quality of life in patients with advanced local-regional disease and a better 5-year survival rate for the patients who underwent lymphadenectomy concomitantly with penile surgery.
286 citations
TL;DR: The evidence on risk factors for penile cancer suggests that preventive measures that could be considered include prevention of phimosis, treatment of chronic inflammatory conditions, limiting PUVA treatment, smoking cessation and prophylactic prevention of HPV infection.
Abstract: Objective: To review the epidemiology of invasive cancer of the penis based on scientific publications identified by a Medline search from 1966-2000 for the keywords penis/penile, cancer/carcinoma and risk as well as the cited references in the identified papers. Results: Strong risk factors (OR >10) identified by case-control studies included phimosis, chronic inflammatory conditions such as balanopostitis and lichen sclerosus et atrophicus and treatment with psoralen and ultraviolet A photo\chemotheraphy (PUVA). A consistent association was found between penile cancer and smoking that was dose-dependent and not explained by investigated confounding factors such as sexual history. Sexual history and self-reported history of condyloma were associated with a 3-5-fold increased penile cancer risk. Cervical cancer in the wife was not consistently associated with cancer of the penis in the husband. Circumcision was associated with penile cancer risk in ecological studies. In a case-control study, circumcision...
278 citations
TL;DR: The rationale, technique and preliminary results of a modified inguinal lymphadenectomy in which the lateral and caudal extents of nodal excision are reduced, and the saphenous veins are preserved also are presented.
276 citations
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Journal Article•
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TL;DR: There was little point in preserving penile length except for psychological reasons, as few cases were having regular sexual intercourse when their disease was diagnosed.
Abstract: SUMMARY AND CONCLUSIONS
Forty–six cases of carcinoma of the penis treated primarily by surgery were reviewed. The following conclusions were reached:
1
Clinical staging as determined at the initial examination was of little value.
2
Pathological division into “solid” or “cord” pattern was of great importance in selecting cases with a good (solid) or poor prognosis (cord). The degree of differentiation was of much less prognostic value.
3
Urinary troubles were rare following a partial or radical amputation.
4
There was little point in preserving penile length except for psychological reasons, as few cases were having regular sexual intercourse when their disease was diagnosed.
We would like to thank Mr W. Keith Yeates of the Department of Urology, Newcastle General Hospital, for permission to include a number of his cases in this series.
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47 citations