Carcinostatic activity of thiosemicarbazones of formyl heteroaromatic compounds. VI. 1-Formylisoquinoline derivatives bearing additional ring substituents, with notes on mechanism of action.
01 Nov 1970-Journal of Medicinal Chemistry (American Chemical Society)-Vol. 13, Iss: 6, pp 1117-1124
About: This article is published in Journal of Medicinal Chemistry.The article was published on 1970-11-01. It has received 115 citations till now. The article focuses on the topics: Ring (chemistry).
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TL;DR: In this paper, Generals survey has shown that thiosemicarbazone complexes can be formed by transition metal complexes, including d2 complexes, d3 complexes and d4 complexes.
734 citations
01 Jan 1991
TL;DR: The nature of metal complexes of heterocyclic thiosemicarbazones reported in the literature through 1989 have been reviewed with an emphasis on variations in stoichiometry and stereochemistry as discussed by the authors.
Abstract: The nature of metal complexes of heterocyclic thiosemicarbazones reported in the literature through 1989 have been reviewed with an emphasis on variations in stoichiometry and stereochemistry. A brief introduction is followed by a survey of the biological activity of the uncomplexed thiosemicarbazones. Next is a section on the chemical nature of thiosemicarbazones including a discussion of preparative methods, modes of coordination and isomerism. This is followed by a discussion of structural information and biological activity of the iron(III), iron(II), copper(II), cobalt(III), cobalt(II) and nickel(II) complexes of heterocyclic thiosemicarbazones. Short sections on the biological activity of other chelating thiosemicarbazones and metal complexes are also included.
435 citations
TL;DR: The reduction potential of the thiosemicarbazone ligand in a Cu(II) complex, the strength of the ligand field and various spectral properties can be correlated to the inhibitory activity.
Abstract: More than 75 substituted thiosemicarbazones and a number of metal complexes of each have been assayed for their antifungal activity. Their activity is significantly affected by the substituted groups attached at both1
N and4
N of the thiosemicarbazone moiety. Greatest activity occurs for 2-substituted pyridine thiosemicarbazones with differences observed for 2-formylpyridine, 2-acetylpyridine and 2-benzoylpyridine derivatives and their metal complexes. Further, there are activity differences for4
N-alkyl-,4
N-aryl-,4
N-dialkyl- and 3-azacyclothiosemicarbazones and their metal complexes as well as changes in the substituent size among each of these subgroups. Cu(II) complexes are often more active than the uncomplexed thiosemicarbazones, with the latter showing similar activity to Ni(II) complexes in many instances. The reduction potential of the thiosemicarbazone ligand in a Cu(II) complex, the strength of the ligand field and various spectral properties can be correlated to the inhibitory activity.
276 citations
TL;DR: A series of 3- and 5-methylthiophene-2-carboxaldehyde alpha-(N)-heterocyclichydrazones were synthesized and submitted to an in vitro investigation of their anticancer, anti-HIV and antimicrobial activities, where some of the newly synthesized compounds were found to possess antiproliferative properties.
157 citations
TL;DR: In this paper, the reactions of bis(cyclopentadienyl)titanium(IV)/zirconium(IV) dichloride with a new class of organometallic thiosemicarbazones (LH), derived by condensing acetylferrocene with substituted thiOSEmicarazides, have been studied and two types of bimetallic products, viz.
Abstract: The reactions of bis(cyclopentadienyl)titanium(IV)/zirconium(IV) dichloride with a new class of organometallic thiosemicarbazones (LH), derived by condensing acetylferrocene with substituted thiosemicarbazides, have been studied and two types of bimetallic products, viz. [Cp2M(L)Cl] (M = Ti or Zr) and [CpZr(L)3], have been isolated. On the basis of various physicochemical and spectral studies, five- and seven-coordinate structures have been assigned to these derivatives, respectively. Attempts have been made to establish a correlation between biological activity and the structures of the products.
153 citations