Cardiac MRI in Patients with Prolonged Cardiorespiratory Symptoms after Mild to Moderate COVID-19.
Dmitrij Kravchenko,Alexander Isaak,Sebastian Zimmer,Narine Mesropyan,Matthäus Reinert,Anton Faron,Claus Christian Pieper,Annkristin Heine,Markus Velten,Jacob Nattermann,Daniel Kuetting,Georg D. Duerr,Ulrike I. Attenberger,Julian A. Luetkens +13 more
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TLDR
Lima et al. as mentioned in this paper explored the relationship between chronic COVID-19 and myocardial injury and inflammation as an underlying cause of the persistent complaints in previously healthy individuals, and found that myocardious inflammation and edema were comparable between participants with CCS and control participants.Abstract:
Background Myocardial injury and inflammation at cardiac MRI in patients with COVID-19 have been described in recent publications. Concurrently, a chronic COVID-19 syndrome (CCS) after SARS-CoV-2 infection has been observed and manifests with symptoms such as fatigue and exertional dyspnea. Purpose To explore the relationship between CCS and myocardial injury and inflammation as an underlying cause of the persistent complaints in previously healthy individuals. Materials and Methods In this prospective study from January 2021 to April 2021, study participants without known cardiac or pulmonary diseases prior to SARS-CoV-2 infection who had persistent CCS symptoms such as fatigue or exertional dyspnea after convalescence and healthy control participants underwent cardiac MRI. The cardiac MRI protocol included evaluating the T1 and T2 relaxation times, extracellular volume, T2 signal intensity ratio, and late gadolinium enhancement (LGE). Student t tests, Mann-Whitney U tests, and χ2 tests were used for statistical analysis. Results Forty-one participants with CCS (mean age, 39 years ± 13 [standard deviation]; 18 men) and 42 control participants (mean age, 39 years ± 16; 26 men) were evaluated. The median time between the initial incidence of mild to moderate COVID-19 not requiring hospitalization and undergoing cardiac MRI was 103 days (interquartile range, 88-158 days). Troponin T levels were normal. Parameters indicating myocardial inflammation and edema were comparable between participants with CCS and control participants (T1 relaxation times: 978 msec ± 23 vs 971 msec ± 25 [P = .17]; T2 relaxation times: 53 msec ± 2 vs 52 msec ± 2 [P = .47]; T2 signal intensity ratios: 1.6 ± 0.2 vs 1.6 ± 0.3 [P = .10]). Visible myocardial edema was present in none of the participants. Three of 41 (7%) participants with CCS demonstrated nonischemic LGE, whereas no participants in the control group demonstrated nonischemic LGE (0 of 42 [0%]; P = .07). None of the participants fulfilled the 2018 Lake Louise criteria for the diagnosis of myocarditis. Conclusion Individuals with chronic COVID-19 syndrome who did not undergo hospitalization for COVID-19 did not demonstrate signs of active myocardial injury or inflammation at cardiac MRI. © RSNA, 2021 Online supplemental material is available for this article. See also the editorial by Lima and Bluemke in this issue.read more
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Combined Cardiac Fluorodeoxyglucose-Positron Emission Tomography/Magnetic Resonance Imaging Assessment of Myocardial Injury in Patients Who Recently Recovered From COVID-19.
Kate Hanneman,Christian Houbois,Alice Schoffel,Dakota Gustafson,Robert M. Iwanochko,Bernd J. Wintersperger,Rosanna Chan,Jason E. Fish,Kathryn L. Howe,Paaladinesh Thavendiranathan +9 more
TL;DR: In this study of patients recently recovered from COVID-19, myocardial inflammation was identified on PET in a small proportion of patients, was associated with cardiac MRI abnormalities and elevated inflammatory blood markers at baseline, and improved at follow-up.
Journal ArticleDOI
Long COVID and the cardiovascular system—elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial and Pericardial Diseases
Mariann Gyöngyösi,Pilar Alcaide,Folkert W. Asselbergs,Bianca J. J. M. Brundel,Giovanni G. Camici,Paula A. da Costa Martins,Péter Ferdinandy,Marianna Fontana,Henrique Girão,Massimiliano Gnecchi,Can Gollmann-Tepeköylü,Petra Kleinbongard,Thomas Krieg,Rosalinda Madonna,M. Paillard,Antonis Pantazis,R. Perrino,Maurizio Pesce,Gabriele G. Schiattarella,Joost P.G. Sluijter,Sabine Steffens,Carsten Tschöpe,Sophie Van Linthout,Sean M. Davidson +23 more
TL;DR: In this article , the authors aim to provide insight into the possible causes and therapeutic options available for the cardiovascular manifestations of long COVID, including chronic fatigue, chest pain, ECG abnormalities, postural orthostatic tachycardia, or newly developed supraventricular or ventricular arrhythmias.
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Impact of COVID-19 on Cardiovascular Disease
TL;DR: A review of the literature reporting an interaction between coronavirus disease 2019 and CVD, review potential mechanisms underlying this interaction, and discuss preventive and treatment strategies and their interference with CVD that were evaluated since the onset of the COVID-19 pandemic as mentioned in this paper .
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Cardiac magnetic resonance follow-up of COVID-19 vaccine associated acute myocarditis
Dmitrij Kravchenko,Alexander Isaak,Narine Mesropyan,Leon M Bischoff,Claus Christian Pieper,Ulrike I. Attenberger,Daniel Kuetting,Sebastian Zimmer,C. Hart,Julian A. Luetkens +9 more
TL;DR: In this article , a follow-up study of nine patients with COVID-19 vaccine associated acute myocarditis showed a complete resolution of visual myocardial edema while also demonstrating a reduction in overall LGE extent from baseline to followup.
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Long-term comprehensive cardiopulmonary phenotyping of COVID-19
Lucas M. Kimmig,Zvonimir A. Rako,S. Ziegler,Manuel J. Richter,Ashkan Tolou G.S.,Fritz Roller,Friedrich Grimminger,István Vadász,Werner Seeger,Susanne Herold,Khodr Tello,Ulrich Matt +11 more
TL;DR: In this paper , the authors report on 71 patients who underwent comprehensive, longitudinal testing in regular intervals for up to 12 months after their initial COVID-19 diagnosis, including pulmonary function testing, cardiopulmonary exercise testing, dedicated left and right heart echocardiography, lung ultrasonography, and cardiac MRI.
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Modified Look-Locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart
Daniel Messroghli,Aleksandra Radjenovic,Sebastian Kozerke,David M. Higgins,Mohan U. Sivananthan,John P. Ridgway +5 more
TL;DR: A novel pulse sequence scheme is presented that allows the measurement and mapping of myocardial T1 in vivo on a 1.5 Tesla MR system within a single breath‐hold and provides high‐resolution T1 maps of human myocardium in native and post‐contrast situations within asingle breath-hold.
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