Catalyst-free, one-pot, three-component synthesis of 5-amino-1,3-aryl-1 $$H$$ -pyrazole-4-carbonitriles in green media
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...to give pyridazine derivatives that are found to be good intermediates for the formation of fused heterocycles.(55) The reaction of MND with diazonium chloride salts of aniline derivatives yields intermediate substituted arylhydrazones 110a–b, that readily cyclizes in basic medium providing pyridazinimine derivatives 111a–b (Scheme 29)....
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"Catalyst-free, one-pot, three-compo..." refers background in this paper
...The pyrazole motif makes the core structure of blockbuster drugs such as Celebrex(R) [41] and Viagra(R) [42] that act as PDE-5 inhibitors, Zoniporide [43] as sodium hydrogen ion exchanger inhibitors, 1-aryl-5-aminopyrazole as NPY5 antagonist [44], and PNU-32945 as HIV-reverse transcriptase inhibitors [45] (Fig....
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"Catalyst-free, one-pot, three-compo..." refers background in this paper
...The pyrazole motif makes the core structure of blockbuster drugs such as Celebrex(R) [41] and Viagra(R) [42] that act as PDE-5 inhibitors, Zoniporide [43] as sodium hydrogen ion exchanger inhibitors, 1-aryl-5-aminopyrazole as NPY5 antagonist [44], and PNU-32945 as HIV-reverse transcriptase inhibitors [45] (Fig....
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