Catalytic Mechanisms of Enzymic Glycosyl Transfer
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Cites background from "Catalytic Mechanisms of Enzymic Gly..."
...Reaction with retention of con¢guration involves a twostep mechanism in which proton transfer occurs to and from an oxygen atom in an equatorial position at the anomeric center [202] (Fig....
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Cites background from "Catalytic Mechanisms of Enzymic Gly..."
...if the structural geometry is or is not conserved [24, 119]....
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536 citations
Cites background from "Catalytic Mechanisms of Enzymic Gly..."
...Hydrolases (and sequence-related transferases) acting on starch are members of the α-amylase superfamily, which consists of a large number of primary sequence-related enzymes with a retaining catalytic mechanism [76], liberating groups in the α-configuration....
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436 citations
Cites background from "Catalytic Mechanisms of Enzymic Gly..."
...In an attempt to localize the catalytic residues, each domain was searched for strictly conserved amino acids having a side chain with an appropriate reactivity (39) to catalyze an acidbase reaction similar to that catalyzed by glycosyl hydrolases (36)....
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