Catestatin Gly364Ser Variant Alters Systemic Blood Pressure and the Risk for Hypertension in Human Populations via Endothelial Nitric Oxide Pathway
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Cites background from "Catestatin Gly364Ser Variant Alters..."
...WT-CST differs from its variant not only in the secondary structures, but also in the interactions with the β2-adrenergic receptor, suggesting that Gly364Ser-CST fails in binding to the β2-adrenergic receptor (Kiranmayi et al., 2016)....
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Cites background from "Catestatin Gly364Ser Variant Alters..."
...Recently, the catestatin Gly364Ser allele was associated with enhanced risk for hypertension in Indian and Japanese populations [18, 54]....
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References
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"Catestatin Gly364Ser Variant Alters..." refers result in this paper
...This is similar to a previous study reporting that the 12Ala allele in the peroxisome proliferator– activated receptor-γ2 did not offer the same protective role in Indians as it did in Caucasians.60 Such contradictory associations of an allele provide evidence for heterogeneity in different populations and underscore the need for carrying out association studies in diverse ethnic populations to draw more accurate conclusions in each population....
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...This is similar to a previous study reporting that the 12Ala allele in the peroxisome proliferator– activated receptor-γ2 did not offer the same protective role in Indians as it did in Caucasians.(60) Such contradictory associations of an allele provide evidence for heterogeneity in different populations and underscore the need for carrying out association studies in diverse ethnic populations to draw more accurate conclusions in each population....
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...Of note, in a Southern Californian population, the 364Ser allele displayed association with diminished DBP levels, especially in men; however, the effect was not consistently observed for SBP or in women.39 Conversely, the 364Ser allele was associated with elevated SBP and MAP levels in a Japanese population (Table 2).59 Thus, 364Ser allele seems to exert directionally concordant effects on BP in several Asian populations (South Indian, North Indian, and Japanese) although not in Caucasians....
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"Catestatin Gly364Ser Variant Alters..." refers background in this paper
...Many functionally active DNA variants have been discovered in the promoter, coding and 3′-untranslated regions of the human CHGA gene.(7,18) Resequencing of the...
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...Previous studies have discovered the occurrence of common SNPs in the CHGA promoter as well as coding regions.(18,19,39) Many of these SNPs have been found to be functionally active, either in altering the transcriptional activity of the promoter(18) or the potencies of the peptides they are found in....
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...ise of providing small, yet important, clues in elucidating the mechanism for the development of hypertension.(18) However,...
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...The minor alleles at -1018, -415, and -57 bp positions of the CHGA promoter give rise to one of the 5 common CHGA promoter haplotypes (GTTTGCCT) which shows higher promoter activity as compared with the WT consensus haplotype (GATTGTCC).(18) This would mean that the 364Ser carriers may have a more active promoter leading to greater levels of the parent CHGA molecule being produced....
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...The 8 SNPs in the CHGA promoter form haplotypes which differ from each other in terms of their transcriptional activity.(18) The minor alleles at -1018, -415, and -57 bp positions of the CHGA promoter give rise to one of the 5 common CHGA promoter haplotypes (GTTTGCCT) which shows higher promoter activity as compared with the WT consensus haplotype (GATTGTCC)....
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