Journal ArticleDOI
Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments.
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TLDR
This review shows that the antiepileptic effects of loop diuretics described in the pertinent literature are based on widely heterogeneous mechanisms ranging from actions on both neuronal NKCC1 and KCC2 to modulation of the brain extracellular volume fraction.About:
This article is published in Neuropharmacology.The article was published on 2013-06-01. It has received 245 citations till now. The article focuses on the topics: Bumetanide & GABAergic.read more
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Cation-chloride cotransporters in neuronal development, plasticity and disease
TL;DR: This work has shown that one family of ion transporters, cation-chloride cotransporters (CCCs), and in particular K+–Cl− cOTransporter 2 (KCC2), have seminal roles in shaping GABAergic signalling and neuronal connectivity.
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New avenues for anti-epileptic drug discovery and development
TL;DR: It is proposed that future anti-epileptic drug development may be improved through a new joint endeavour between academia and the industry, through the identification and application of tools for new target-driven approaches, and through comparative preclinical proof-of-concept studies and innovative clinical trials designs.
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Seizures and Epilepsy: An Overview for Neuroscientists
Carl E. Stafstrom,Lionel Carmant +1 more
TL;DR: The clinical aspects of seizures and epilepsy are defined, diagnostic methods are reviewed, various clinical syndromes are discussed, and aspects of differential diagnosis, treatment, and prognosis are considered to enable neuroscientists to formulate basic and translational research questions.
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Drug Resistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options.
TL;DR: The current understanding of the molecular, genetic, and structural mechanisms of drug resistance in epilepsy and how the problem might be overcome are reviewed.
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The GABA excitatory/inhibitory developmental sequence: A personal journey
TL;DR: A personal history of how an unexpected observation led to novel concepts in developmental neurobiology and putative treatments of autism and other developmental disorders is presented.
References
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Journal ArticleDOI
The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation.
Claudio Rivera,Juha Voipio,John A. Payne,Eva Ruusuvuori,Hannele Lahtinen,Karri Lamsa,Ulla Pirvola,Mart Saarma,Kai Kaila +8 more
TL;DR: It is shown that, in pyramidal neurons of the rat hippocampus, the ontogenetic change in GABAA-mediated responses from depolarizing to hyperpolarizing is coupled to a developmental induction of the expression of the neuronal Cl−-extruding K+/Cl − co-transporter, KCC2 (ref. 7).
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Incidence of Epilepsy and Unprovoked Seizures in Rochester, Minnesota: 1935–1984
TL;DR: Age‐and gender‐specific incidence trends were similar to those of epilepsy, but a higher proportion of cases was of unknown etiology and was characterized by generalized onset seizures.
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Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy.
Alan Ward,Stephen P. Clissold +1 more
TL;DR: Pentoxifylline offers a well-tolerated and effective alternative to the treatment options available for patients with peripheral vascular disease and in isolated studies proved to be superior to drugs such as co-dergocrine mesylate, adenosine and pyrithioxine.
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Spatio-temporal transcriptome of the human brain
Hyo Jung Kang,Yuka Imamura Kawasawa,Feng Cheng,Ying Zhu,Xuming Xu,Mingfeng Li,André M. M. Sousa,André M. M. Sousa,Mihovil Pletikos,Mihovil Pletikos,Kyle A. Meyer,Goran Sedmak,Goran Sedmak,Tobias Guennel,Yurae Shin,Matthew B. Johnson,Željka Krsnik,Simone Mayer,Sofia Fertuzinhos,Sheila Umlauf,Steven Lisgo,Alexander O. Vortmeyer,Daniel R. Weinberger,Shrikant Mane,Thomas M. Hyde,Thomas M. Hyde,Anita Huttner,Mark Reimers,Joel E. Kleinman,Nenad Sestan +29 more
TL;DR: The generation and analysis of exon-level transcriptome and associated genotyping data, representing males and females of different ethnicities, from multiple brain regions and neocortical areas of developing and adult post-mortem human brains, finds that 86 per cent of the genes analysed were expressed, and that 90 per cent were differentially regulated at the whole-transcript or exon level acrossbrain regions and/or time.
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Sensors and regulators of intracellular pH
TL;DR: A dynamic, finely tuned balance between proton-extruding andProton-importing processes underlies pH homeostasis not only in the cytosol, but in other cellular compartments as well.