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Journal ArticleDOI

Cationic peptide-based salt-responsive antibacterial hydrogel dressings for wound healing.

TL;DR: In this article, a cationic peptide-based, salt-responsive hydrogel dressing with triple functions of antifouling, bactericidal, and bacterial release was developed by combining e-poly-l-lysine, poly(ethylene glycol) diglycidyl ether, and poly(DVBAPS-co-GMA).
About: This article is published in International Journal of Biological Macromolecules.The article was published on 2021-09-10. It has received 15 citations till now. The article focuses on the topics: Self-healing hydrogels & Biocompatibility.
Citations
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Journal ArticleDOI
TL;DR: An updated report on the advancement of peptide-based hydrogels research activity in recent years in the field of anticancer drug delivery, antimicrobial and wound healing materials, 3D bioprinting and tissue engineering, and vaccines is presented.
Abstract: Peptide-based hydrogels have attracted increasing attention for biological applications and diagnostic research due to their impressive features including biocompatibility and biodegradability, injectability, mechanical stability, high water absorption capacity, and tissue-like elasticity. The aim of this review will be to present an updated report on the advancement of peptide-based hydrogels research activity in recent years in the field of anticancer drug delivery, antimicrobial and wound healing materials, 3D bioprinting and tissue engineering, and vaccines. Additionally, the biosensing applications of this key group of hydrogels will be discussed mainly focusing the attention on cancer detection.

19 citations

Journal ArticleDOI
TL;DR: Wang et al. as mentioned in this paper presented a new biomimetic natural-synthetical combination by integrating Osteichthyes-extracted gelatins into hydrophilic polymeric networks to form unique tough, adhesive, self-healable composite hydrogels.
Abstract: Development of biomimetic hydrogel-based wound dressing is highly desirable for addressing life-threatening infectious skin injuries but has proved to be extremely challenging. However, poor tissue adhesive performance, stretchability and difficult fixation lead to conventional wound dressings failing to adapt to dynamic wounds with high-frequency movement or special fluctuant positions. Herein, we present a new biomimetic natural-synthetical combination by integrating Osteichthyes-extracted gelatins into hydrophilic polymeric networks to form unique tough, adhesive, self-healable composite hydrogels. The resultant Gelatin/PHEAA hydrogel without any growth factors/fungicides has high mechanical strength (∼1.0 MPa), high interfacial toughness (>1000 J/m2), and remarkable antifouling activity, enabling the hydrogel to effectively inhibit bacterial proliferation and promote the wound healing. Moreover, due to the abundant hydrogen bonds in composite crosslinked networks, the Gelatin/PHEAA hydrogels maintain high, repeatable adhesion even in high dynamic cases, regardless of wet or dry environments and the types of solid nonporous substrates. Further in vitro and in vivo full-thickness skin defect model confirms that the Osteichthyes-extracted proteins can accelerate collagen deposition and vascular regeneration, leading to a faster wound closure efficiency. Ultimately, we believe that the designed tough Gelatin/PHEAA hydrogels can be high-value candidates for managing rapid wound healing, while the proposed structural biomimetic combination can inspire researchers to design more interesting and effective biomaterials for clinical translation and health care.

14 citations

Journal ArticleDOI
TL;DR: In this paper , the fabrication of antibacterial hydrogel wound dressings and the challenges associated with the cross-linking methods and chemistry of the materials are discussed, and an outlook on long-lasting antibacterial effects, a broader antibacterial spectrum, diversified hyrogel forms, and the future development prospects of the field is provided.
Abstract: Hydrogels are essential biomaterials due to their favorable biocompatibility, mechanical properties similar to human soft tissue extracellular matrix, and tissue repair properties. In skin wound repair, hydrogels with antibacterial functions are especially suitable for dressing applications, so novel antibacterial hydrogel wound dressings have attracted widespread attention, including the design of components, optimization of preparation methods, strategies to reduce bacterial resistance, etc. In this review, we discuss the fabrication of antibacterial hydrogel wound dressings and the challenges associated with the crosslinking methods and chemistry of the materials. We have investigated the advantages and limitations (antibacterial effects and antibacterial mechanisms) of different antibacterial components in the hydrogels to achieve good antibacterial properties, and the response of hydrogels to stimuli such as light, sound, and electricity to reduce bacterial resistance. Conclusively, we provide a systematic summary of antibacterial hydrogel wound dressings findings (crosslinking methods, antibacterial components, antibacterial methods) and an outlook on long-lasting antibacterial effects, a broader antibacterial spectrum, diversified hydrogel forms, and the future development prospects of the field.

9 citations

Journal ArticleDOI
TL;DR: In this paper , a spatiotemporal self-strengthening injectable hydrogel via manipulating the time-dependent cross-linking effects after the Schiff base reaction was proposed.
Abstract: As the forefront of the digestive system, a mouth in a high moist microenvironment is easy to breed bacteria and the inevitable injury from oral surgeries will cause a series of physiological disorders. The injectable hydrogels are promising biomaterials to solve this challenge, but the limited mechanical performance and weak mechanical adjustment are insufficient to fit in the whole healing process. Herein, we propose and design a new spatiotemporal self-strengthening injectable hydrogel via manipulating the time-dependent cross-linking effects after the Schiff base reaction. The resultant hydrogels possess various promising properties and functions, including rapid initial gelation efficiency (∼30 s), spatiotemporal adjustable mechanical strength, great antifouling property and biocompatibility, leading to effective promote oral tissue regeneration and bone repair. We believe both our concept and spatiotemporal self-strengthening injectable hydrogels will provide new insight into the hydrogel-based wound dressing and broaden the application of the bioinspired hydrogels in biomedical fields.

8 citations

Journal ArticleDOI
TL;DR: Both in vivo and in vitro evidence indicates biocompatibility, and strong healing efficiency, indicating that poly (AAm-co-SVBA) (PAS) hydrogels as new wound healing candidates with biomedical applications.
Abstract: Any sort of wound injury leads to the destruction of skin integrity and wound formation, causing millions of deaths every year and accounting for 10% of death rate insight into various diseases. The ideal biological wound dressings are expected to possess extraordinary mechanical characterization, cytocompatibility, adhesive properties, antibacterial properties, and conductivity of endogenous electric current to enhance the wound healing process. Recent studies have demonstrated that biomedical hydrogels can be used as typical wound dressings to accelerate the whole healing process due to them having a similar composition structure to skin, but they are also limited by ideal biocompatibility and stable mechanical properties. To extend the number of practical candidates in the field of wound healing, we designed a new structural zwitterion poly[3-(dimethyl(4-vinylbenzyl) ammonium) propyl sulfonate] (SVBA) into a poly-acrylamide network, with remarkable mechanical properties, stable rheological property, effective antibacterial properties, strong adsorption, high penetrability, and good electroactive properties. Both in vivo and in vitro evidence indicates biocompatibility, and strong healing efficiency, indicating that poly (AAm-co-SVBA) (PAS) hydrogels as new wound healing candidates with biomedical applications.

6 citations

References
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Journal ArticleDOI
TL;DR: The antibacterial electroactive injectable hydrogel dressing prolonged the lifespan of dressing relying on self-healing ability and significantly promoted the in vivo wound healing process attributed to its multifunctional properties, meaning that they are excellent candidates for full-thickness skin wound healing.

1,326 citations

Journal ArticleDOI
06 Mar 2017-ACS Nano
TL;DR: This free-standing, adhesive, tough, and biocompatible hydrogel may be more convenient for surgical applications than adhesives that involve in situ gelation and extra agents.
Abstract: Adhesive hydrogels are attractive biomaterials for various applications, such as electronic skin, wound dressing, and wearable devices. However, fabricating a hydrogel with both adequate adhesiveness and excellent mechanical properties remains a challenge. Inspired by the adhesion mechanism of mussels, we used a two-step process to develop an adhesive and tough polydopamine-clay-polyacrylamide (PDA-clay-PAM) hydrogel. Dopamine was intercalated into clay nanosheets and limitedly oxidized between the layers, resulting in PDA-intercalated clay nanosheets containing free catechol groups. Acrylamide monomers were then added and in situ polymerized to form the hydrogel. Unlike previous single-use adhesive hydrogels, our hydrogel showed repeatable and durable adhesiveness. It adhered directly on human skin without causing an inflammatory response and was easily removed without causing damage. The adhesiveness of this hydrogel was attributed to the presence of enough free catechol groups in the hydrogel, which we...

676 citations

Journal ArticleDOI
21 Nov 2014-Science
TL;DR: The classic paradigms of wound healing are reviewed and how recent discoveries have enriched understanding of this process are evaluated, with an emphasis on cell-based therapies and skin transplantation.
Abstract: The ability of the skin to repair itself after injury is vital to human survival and is disrupted in a spectrum of disorders. The process of cutaneous wound healing is complex, requiring a coordinated response by immune cells, hematopoietic cells, and resident cells of the skin. We review the classic paradigms of wound healing and evaluate how recent discoveries have enriched our understanding of this process. We evaluate current and experimental approaches to treating cutaneous wounds, with an emphasis on cell-based therapies and skin transplantation.

528 citations

Journal ArticleDOI
TL;DR: The pathophysiology of chronic wounds is discussed and then the materials used for engineering drug delivery systems are discussed, and the architecture of the delivery platform and its ability to modulate drug delivery are discussed.

440 citations

Journal ArticleDOI
TL;DR: Biodegradable Cur-M-H composite might have great application for wound healing because of its well tissue adhesiveness and ability to release curcumin in an extended period.

420 citations