CC chemokine ligand 19 might act as the main bursal T cell chemoattractant factor during IBDV infection.
Qiuxia Wang,Changbo Ou,Wei Xiaobing,Yan Yu,Jinqing Jiang,Yanhong Zhang,Jinyou Ma,Xingyou Liu,Gaiping Zhang +8 more
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TLDR
The data suggest that CCL19 acts as a chicken PWBC chemotactic factor and facilitate the infiltration of PWBC (especially T cells) into the bursae after IBDV infection.About:
This article is published in Poultry Science.The article was published on 2019-02-01 and is currently open access. It has received 8 citations till now. The article focuses on the topics: Bursa of Fabricius & CCL19.read more
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Journal ArticleDOI
Macrophage Migration Inhibitory Factor Triggers Inflammatory Responses During Very Virulent Infectious Bursal Disease Virus Infection.
Aijing Liu,Hui Li,Xiaole Qi,Qi Wang,Bo Yang,Tiantian Wu,Nana Yan,Yue Li,Qing Pan,Yulong Gao,Li Gao,Changjun Liu,Yanping Zhang,Hongyu Cui,Kai Li,Yongqiang Wang,Xiaomei Wang +16 more
TL;DR: High-throughput proteomic sequencing showed that chicken macrophage migration inhibitory factor (chMIF) was upregulated uniquely in primary bursal cells infected with vvIBDV compared with infection by nonpathogenic attenuated IBDV, and elucidates critical molecular determinants underlying vv IBDV-mediated initiation of acute inflammation.
Journal ArticleDOI
Differential Response of the Chicken Trachea to Chronic Infection with Virulent Mycoplasma gallisepticum Strain Ap3AS and Vaxsafe MG (Strain ts-304): a Transcriptional Profile.
Sathya N Kulappu Arachchige,Neil D. Young,Pollob K. Shil,Alistair R. Legione,Anna Kanci Condello,Glenn F. Browning,Nadeeka K. Wawegama +6 more
TL;DR: Vaxsafe MG (strain ts-304) is a new vaccine candidate that is efficacious at a lower dose than the current commercial vaccine strain ts-11, from which it is derived and appears to protect the structural and functional integrity of the tracheal mucosa 2 weeks after infection with M. gallisepticum.
Journal ArticleDOI
Effects of infectious bursal disease virus infection on interferon and antiviral gene expression in layer chicken bursa.
Yan Yu,Zhiyong Xu,Yan Liu,Huan Zhang,Changbo Ou,Yanhong Zhang,Ting-Yu Liu,Qiuxia Wang,Jinyou Ma +8 more
TL;DR: Data showed that after the chickens were infected with IBDV, the virus load in the bursa of the Fabricius peaked at 96 h and gradually decreased, and the ZAP change rule was significantly positively correlated with the change rule of the I BDV load.
Journal ArticleDOI
Transcriptome analysis of chicken intraepithelial lymphocyte natural killer cells infected with very virulent infectious bursal disease virus.
Sook Yee Boo,Sheau Wei Tan,Noorjahan Banu Alitheen,Chai Ling Ho,Abdul Rahman Omar,Swee Keong Yeap,Swee Keong Yeap +6 more
TL;DR: This is the first study to examine the whole transcriptome profile of chicken NK cells towards IBDV infection and provides better insight into the early immune response ofChicken NK cells.
Journal ArticleDOI
Bacillus amyloliquefaciens TL Downregulates the Ileal Expression of Genes Involved in Immune Responses in Broiler Chickens to Improve Growth Performance
TL;DR: In this article, RNA-sequencing (RNA-seq)-based transcriptomes of ileal tissues collected from probiotic-fed and control broiler chickens were analyzed to elucidate the effects of the probiotic B. amyloliquefaciens TL, as a feed additive, on the gut immune function.
References
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Journal ArticleDOI
CCR7 and its ligands: balancing immunity and tolerance
TL;DR: This work focuses on the cellular and molecular mechanisms that enable CCR7 and its two ligands, CCL19 and CCL21, to balance immunity and tolerance.
Journal ArticleDOI
Chemokines and leukocyte traffic.
TL;DR: Twenty years after the discovery of chemokines is an appropriate time to review leukocyte traffic and to assess the knowledge and opportunities that have arisen from countless studies of the large and tight-knit family of chemotactic proteins.
Journal ArticleDOI
Chemokines define distinct microenvironments in the developing thymus.
Conrad C. Bleul,Thomas Boehm +1 more
TL;DR: Developing thymocytes respond to chemokines expressed in distinct microenvironments within the thymic stroma in a way that correlates well with the previously observed migration pattern from cortex to medulla.
Journal ArticleDOI
CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency.
Suha Saleh,Ajantha Solomon,Fiona Wightman,Miranda Xhilaga,Paul U. Cameron,Paul U. Cameron,Sharon R Lewin +6 more
TL;DR: A unique action of the chemokines CCL19 and CCL21 is demonstrated and a novel model with which to study HIV-1 latency in vitro is provided and is demonstrated to facilitate efficient entry of HIV- 1 into resting CD4(+) T cells.
Journal ArticleDOI
Infectious bursal disease virus: strains that differ in virulence differentially modulate the innate immune response to infection in the chicken bursa.
Ibrahim Eldaghayes,Lisa Rothwell,Andrew Williams,David R. Withers,Sucharitha Balu,Fred Davison,Peter K. Kaiser +6 more
TL;DR: F52/70 seems to use a "stealth" approach by not inducing the type I IFNs, whereas UK661 down-regulates their expression, which suggests that both viruses modulate the host immune response, although probably by using different mechanisms.
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