CD22, a B cell-specific immunoglobulin superfamily member, is a sialic acid-binding lectin.
Reads0
Chats0
TLDR
Observations indicate that CD22 is a sialic acid-binding lectin and may define a novel functional subset of immunoglobulin superfamily adhesion molecules.About:
This article is published in Journal of Biological Chemistry.The article was published on 1993-04-05 and is currently open access. It has received 241 citations till now. The article focuses on the topics: Sialic acid binding & Sialic Acid Binding Immunoglobulin-like Lectins.read more
Citations
More filters
Journal ArticleDOI
Signal transduction by lymphocyte antigen receptors
Arthur Weiss,Dan R. Littman +1 more
TL;DR: Insight gained from studies of the signaling pathways downstream of TCR and BCR stimulation is likely to contribute significantly to future understanding of mechanisms responsible for lymphocyte differentiation and for the discrimination of self from nonself in developing and mature cells.
Journal ArticleDOI
Biology of Oligodendrocyte and Myelin in the Mammalian Central Nervous System
TL;DR: This review deals with the recent progress related to the origin and differentiation of the oligodendrocytes, their relationships to other neural cells, and functional neuroglial interactions under physiological conditions and in demyelinating diseases.
Journal ArticleDOI
Protein glycosylation. Structural and functional aspects.
Halina Lis,Nathan Sharon +1 more
TL;DR: Examples are given of changes that occur in the carbohydrates of soluble and cell-surface glycoproteins during differentiation, growth and malignancy, which further highlight the important role of these substances in health and disease.
Journal ArticleDOI
CD45: An Emerging Role as a Protein Tyrosine Phosphatase Required for Lymphocyte Activation and Development
TL;DR: Evidence from genetic experiments indicates that CD45 plays a pivotal role in antigen-stimulated proliferation of T lymphocytes and in thymic development, and analysis of CD45 isoform expression has revealed a hitherto unrecognized plasticity in isoform usage by T cells and other leukocytes, adding to the regulatory complexity ofisoform expression.
Journal ArticleDOI
Siglec-mediated regulation of immune cell function in disease
TL;DR: The recent advances in understanding of the roles of Siglecs in the regulation of immune cell function in infectious diseases, inflammation, neurodegeneration, autoimmune diseases and cancer are described.
References
More filters
Journal ArticleDOI
Adhesion receptors of the immune system.
TL;DR: Three families of cell-surface molecules regulate the migration of lymphocytes and the interactions of activated cells during immune responses.
Journal ArticleDOI
Integrins: a family of cell surface receptors.
TL;DR: This brief review of sequence data from embryogenesis, thrombosis, and lymphocyte help and killing is summarized and attempts to clarify the relationships among the members of this family of cell surface receptors.
Journal ArticleDOI
CD44 is the principal cell surface receptor for hyaluronate.
TL;DR: In this paper, the authors have created soluble CD44-immunoglobulin fusion proteins and characterized their reactivity with tissue sections and lymph node high endothelial cells in primary culture.
Journal ArticleDOI
Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins
TL;DR: Endothelial leukocyte adhesion molecule-1 (ELAM-1), a cell surface glycoprotein expressed by cytokine-activated endothelium, mediates the adhesion of blood neutrophils and may be a member of a nascent gene family of cell surface molecules involved in the regulation of inflammatory and immunological events at the interface of vessel wall and blood.
Journal ArticleDOI
VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site
Mariano J. Elices,Laurelee Osborn,Yoshikazu Takada,Carol Crouse,Stefan Luhowskyj,Martin E. Hemler,Roy R. Lobb +6 more
TL;DR: The VCAM-1/VLA-4 ligand-receptor pair may play a major role in the recruitment of mononuclear leukocytes to inflammatory sites in vivo.
Related Papers (5)
The B lymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T cells and α2–6 sialyltransferase, CD75, on B cells
The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion.
Ivan Stamenkovic,Brian Seed +1 more