Journal ArticleDOI
CD69 and regulation of the immune function.
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TLDR
Although a specific ligand for CD69 has not been identified, its wide cellular distribution and the induction of intracellular signals upon CD69 crosslinking suggest a role for the receptor in the biology of hematopoietic cells.Abstract:
CD69, also known as activation inducer molecule, very early activation antigen, MLR-3 and Leu-23, is a member of the natural killer (NK) cell gene complex family of signal transducing receptors. CD69 is as a type II transmembrane glycoprotein with a C-type lectin binding domain in the extracellular portion of the molecule. CD69 expression is induced in vitro on cells of most hematopoietic lineages, including T and B lymphocytes, NK cells, murine macrophages, neutrophils and eosinophils, while it is constitutively expressed on human monocytes, platelets and epidermal Langerhans cells. Although a specific ligand for CD69 has not been identified, its wide cellular distribution and the induction of intracellular signals upon CD69 crosslinking suggest a role for the receptor in the biology of hematopoietic cells. Moreover, certain results indicate that CD69 may be involved in the pathogenesis of such diseases as rheumatoid arthritis, chronic inflammatory liver diseases, mild asthma, and acquired immunodeficiency syndrome.read more
Citations
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References
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TL;DR: Describing de 2 categories de lectines animales: les lectines de type C, calcium-dependantes et les lectine de type S, thiol-dependante.
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Journal ArticleDOI
Interaction of Fc receptor (CD16) ligands induces transcription of interleukin 2 receptor (CD25) and lymphokine genes and expression of their products in human natural killer cells.
TL;DR: Evidence is reported that FcR(CD16) on human NK cells are signal- transducing molecules that, upon ligand binding, induce transcription of genes encoding surface activation molecules and cytokines relevant to NK cell biology and functions and synergize at a post-transcriptional or translational level to enhance NK cell activation.
Journal Article
T cell activation via Leu-23 (CD69).
TL;DR: Although the signal delivered by the CD69 initiates T cell proliferation, it is unable to trigger cytotoxicity programs in CD69+-activated T cells or T cell clones.
Journal ArticleDOI
Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors.
Manuel López-Cabrera,Ana G. Santis,Elena Fernández-Ruiz,R Blacher,F Esch,Paloma Sánchez-Mateos,Francisco Sánchez-Madrid +6 more
TL;DR: Protein sequence homology search revealed that CD69 is a new member of the Ca(2+)-dependent (C-type) lectin superfamily of type II transmembrane receptors, which includes the human NKG2, the rat NKR-P1, and the mouse NKR -P1 families of NK cell-specific genes.