CDK inhibitors: positive and negative regulators of G1-phase progression
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Cites background from "CDK inhibitors: positive and negati..."
...Its level is high in quiescent cells, but after mitogenic stimuli, it is rapidly degraded by the ubiquitin system, allowing the CDK/cyclin complexes to drive the cell into the S phase (409)....
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Additional excerpts
...Several of these molecules, includ(Sherr and Roberts, 1999)....
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1,972 citations
Cites background from "CDK inhibitors: positive and negati..."
...The p21 induction family of CDK inhibitors comprises p21, p27, and p57 (Sherr and Roberts, 1999)....
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...The p21CIP1/WAF1 induction family of CDK inhibitors comprises p21CIP1/WAF1, p27KIP1, and p57KIP2 (Sherr and Roberts, 1999)....
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References
8,339 citations
"CDK inhibitors: positive and negati..." refers background in this paper
...The latter class includes p21 (Gu et al. 1993; Harper et al. 1993; El-Deiry et al. 1993; Xiong et al. 1993a; Dulic et al. 1994; Noda et al. 1994), p27 (Polyak et al....
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...…overexpression of catalytically inactive CDK4 can also reverse a cell cycle block imposed by p16 (Koh et al. 1995; Jiang et al. 1998) or by p53 (Latham et al. 1996), which arrests cells in G1 by inducing p21 (El-Deiry et al. 1993; Dulic et al. 1994; Brugarolas et al. 1995; Deng et al. 1995)....
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...1996), which arrests cells in G1 by inducing p21 (El-Deiry et al. 1993; Dulic et al. 1994; Brugarolas et al. 1995; Deng et al. 1995)....
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...The latter class includes p21Cip1 (Gu et al. 1993; Harper et al. 1993; El-Deiry et al. 1993; Xiong et al. 1993a; Dulic et al. 1994; Noda et al. 1994), p27Kip1 (Polyak et al. 1994a,b; Toyoshima and Hunter 1994), and p57Kip2 (Lee et al. 1995; Matsuoka et al. 1995), all of which contain characteristic…...
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5,726 citations
"CDK inhibitors: positive and negati..." refers background in this paper
...The latter class includes p21 (Gu et al. 1993; Harper et al. 1993; El-Deiry et al. 1993; Xiong et al. 1993a; Dulic et al. 1994; Noda et al. 1994), p27 (Polyak et al....
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...The latter class includes p21Cip1 (Gu et al. 1993; Harper et al. 1993; El-Deiry et al. 1993; Xiong et al. 1993a; Dulic et al. 1994; Noda et al. 1994), p27Kip1 (Polyak et al. 1994a,b; Toyoshima and Hunter 1994), and p57Kip2 (Lee et al. 1995; Matsuoka et al. 1995), all of which contain characteristic…...
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5,509 citations
"CDK inhibitors: positive and negati..." refers background in this paper
...…disruption of Rb or p16 function, or overexpression of cyclin D or CDK4, are common events in human cancer, complete loss of Cip/Kip function has not been observed, cyclin E amplification is rare, and gain-of-function mutations involving cyclin E have not been found (for review, see Sherr 1996)....
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...Conversely, constitutive activation of the D cyclin pathway can reduce or overcome certain mitogen requirements for cell proliferation and thereby contribute to oncogenic transformation (for reviews, see Weinberg 1995; Sherr 1996; Bartkova et al. 1997)....
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...…cyclin E–CDK2 becomes active and completes this process by phosphorylating Rb on additional sites (Matsushime et al. 1994; Meyerson and Harlow 1994; Mittnacht et al. 1994; Kitagawa et al. 1996; Ezhevsky et al. 1997; Lundberg and Weinberg 1998; for review, see Weinberg 1995; Sherr 1996; Taya 1997)....
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4,904 citations
"CDK inhibitors: positive and negati..." refers background in this paper
...Conversely, constitutive activation of the D cyclin pathway can reduce or overcome certain mitogen requirements for cell proliferation and thereby contribute to oncogenic transformation (for reviews, see Weinberg 1995; Sherr 1996; Bartkova et al. 1997)....
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...…cyclin E–CDK2 becomes active and completes this process by phosphorylating Rb on additional sites (Matsushime et al. 1994; Meyerson and Harlow 1994; Mittnacht et al. 1994; Kitagawa et al. 1996; Ezhevsky et al. 1997; Lundberg and Weinberg 1998; for review, see Weinberg 1995; Sherr 1996; Taya 1997)....
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4,770 citations
"CDK inhibitors: positive and negati..." refers background in this paper
...…accumulates progressively as cells age, possibly being induced by a senescence timer (Alcorta et al. 1996; Hara et al. 1996; Palmero et al. 1997; Serrano et al. 1997; Zindy et al. 1997a), whereas p18INK4c and p19INK4d are focally expressed during fetal development and may have roles in…...
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