Cell-cycle checkpoints and cancer
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Cites background from "Cell-cycle checkpoints and cancer"
...In addition, most tumours acquire genomic instability (GIN) that leads to additional mutations as well as chromosomal instability (CIN), a defect responsible for numerical changes in chromosome...
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References
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"Cell-cycle checkpoints and cancer" refers background in this paper
...The identification of a single, major damage-induced phosphorylation site (serine 1981) led to the demonstration of a new mechanism of ATM regulation that permits a rapid and sensitive switch for checkpoint pathway...
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3,048 citations
"Cell-cycle checkpoints and cancer" refers background in this paper
...Initiation of the activities of the PI(3)K (phosphatidylinositol-3-OH kinase)-like kinases (PIKKs), ATM (ataxia insight review articles...
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2,632 citations
"Cell-cycle checkpoints and cancer" refers background in this paper
...ATR exists in a complex with the ATR-interacting protein (ATRIP), both before and after exposure to stresses such as ultraviolet irradiatio...
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2,579 citations
"Cell-cycle checkpoints and cancer" refers background in this paper
...Transducing the signal To efficiently spread the alert signal and orchestrate the global cellular response to DNA damage that is usually inflicted to only a few sites within the vast genome, the proximal checkpoint kinases ATM and ATR (ref...
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