Cell Death in the Pathogenesis of Heart Disease: Mechanisms and Significance
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1,565 citations
Cites background from "Cell Death in the Pathogenesis of H..."
...Caspase-3 acts as the cell’s executioner by proteolyzing many cellular proteins (Broughton et al., 2009; Kroemer et al., 2007; Whelan et al., 2010)....
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...6.4), although there is considerable cross talk between the two (Broughton et al., 2009; Kroemer et al., 2007; Whelan et al., 2010)....
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..., Bax, Bak) into the outer mitochondrial membrane (Broughton et al., 2009; Kroemer et al., 2007; Whelan et al., 2010)....
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...…leading to dissipation of the proton electrochemical gradient, with subsequent ATP depletion, further ROS production, and swelling and rupture of mitochondrial membranes. respectively, whereas endoG mediates DNA fragmentation (Broughton et al., 2009; Kroemer et al., 2007; Whelan et al., 2010)....
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...4), although there is considerable cross talk between the two (Broughton et al., 2009; Kroemer et al., 2007; Whelan et al., 2010)....
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918 citations
Cites background from "Cell Death in the Pathogenesis of H..."
...Preventing cardiac cell death has been suggested to be an effective cardioprotective strategy (34)....
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641 citations
587 citations
Cites background from "Cell Death in the Pathogenesis of H..."
...Parkinson`s as well a number of pathophysiological processes such as ischemic strokes and heart attacks [8,41,55,334]....
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...This relatively simple example of cross-talk between apparently distinct apoptotic pathways further serves to illustrate a common theme of the complex interrelationships that is now commonly observed in the different processes involved in regulating cell death (see also below) [8,13,17,18]....
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533 citations
References
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