Cell‐laden Microengineered and Mechanically Tunable Hybrid Hydrogels of Gelatin and Graphene Oxide
Su Ryon Shin,Su Ryon Shin,Behnaz Aghaei-Ghareh-Bolagh,Behnaz Aghaei-Ghareh-Bolagh,Tram T. Dang,Seda Nur Topkaya,Seda Nur Topkaya,Xiguang Gao,Seung Yun Yang,Sung Mi Jung,Jong Hyun Oh,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Xiaowu Shirley Tang,Ali Khademhosseini,Ali Khademhosseini +15 more
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TLDR
Graphene oxide inside GelMA hydrogels enhances their mechanical properties and reduces UV-induced cell damage while preserving their favorable characteristics for 3D cell encapsulation.Abstract:
Incorporating graphene oxide inside GelMA hydrogels enhances their mechanical properties and reduces UV-induced cell damage while preserving their favorable characteristics for 3D cell encapsulation. NIH-3T3 fibroblasts encapsulated in GO-GelMA microgels demonstrate excellent cellular viability, proliferation, spreading, and alignment. GO reinforcement combined with a multi-stacking approach offers a facile engineering strategy for the construction of complex artificial tissues.read more
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Journal ArticleDOI
Proceedings of the National Academy of Sciences
TL;DR: It is shown that the full set of hydromagnetic equations admit five more integrals, besides the energy integral, if dissipative processes are absent, which made it possible to formulate a variational principle for the force-free magnetic fields.
Journal ArticleDOI
Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels
Kan Yue,Kan Yue,Grissel Trujillo-de Santiago,Grissel Trujillo-de Santiago,Mario Moises Alvarez,Ali Tamayol,Ali Tamayol,Nasim Annabi,Nasim Annabi,Nasim Annabi,Ali Khademhosseini,Ali Khademhosseini,Ali Khademhosseini +12 more
TL;DR: Gelatin methacryloyl (GelMA) hydrogels have been widely used for various biomedical applications due to their suitable biological properties and tunable physical characteristics and are demonstrated in a wide range of tissue engineering applications including engineering of bone, cartilage, cardiac, and vascular tissues, among others.
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Graphene-based nanomaterials for drug delivery and tissue engineering.
TL;DR: This article presents a comprehensive review of various types and properties of graphene family nanomaterials and highlights how these properties are being exploited for drug delivery and tissue engineering applications.
Journal ArticleDOI
Mussel-Inspired Adhesive and Tough Hydrogel Based on Nanoclay Confined Dopamine Polymerization.
Lu Han,Xiong Lu,Xiong Lu,Liu Kezhi,Kefeng Wang,Liming Fang,Lu-Tao Weng,Hongping Zhang,Youhong Tang,Fuzeng Ren,Cancan Zhao,Guoxing Sun,Rui Liang,Zongjin Li +13 more
TL;DR: This free-standing, adhesive, tough, and biocompatible hydrogel may be more convenient for surgical applications than adhesives that involve in situ gelation and extra agents.
Journal ArticleDOI
Two‐Dimensional Nanomaterials for Biomedical Applications: Emerging Trends and Future Prospects
TL;DR: The unique characteristics that make 2D nanoparticles so valuable are described, as well as the biocompatibility framework that has been investigated so far, to capture the growing trend of 2D nanomaterials for biomedical applications and to identify promising new research directions.
References
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Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
Journal ArticleDOI
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
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Hydrogels as Extracellular Matrix Mimics for 3D Cell Culture
TL;DR: The use of both synthetic and natural hydrogels as scaffolds for three-dimensional cell culture as well as synthetic hydrogel hybrids that incorporate sophisticated biochemical and mechanical cues as mimics of the native extracellular matrix are discussed.
Journal ArticleDOI
Cell-laden microengineered gelatin methacrylate hydrogels.
Jason W. Nichol,Sandeep T. Koshy,Sandeep T. Koshy,Sandeep T. Koshy,Hojae Bae,Hojae Bae,Chang M. Hwang,Chang M. Hwang,Seda Yamanlar,Seda Yamanlar,Ali Khademhosseini,Ali Khademhosseini +11 more
TL;DR: GelMA hydrogels could be useful for creating complex, cell- responsive microtissues, such as endothelialized microvasculature, or for other applications that require cell-responsive microengineered hydrogELs.
Journal ArticleDOI
Proceedings of the National Academy of Sciences
TL;DR: It is shown that the full set of hydromagnetic equations admit five more integrals, besides the energy integral, if dissipative processes are absent, which made it possible to formulate a variational principle for the force-free magnetic fields.