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Cell-Penetrating Peptides: From Basic Research to Clinics
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TLDR
In this article, cell-penetrating peptides (CPPs) have been used to increase medicament concentrations in areas that are difficult to access, which can transport into the cell a wide variety of biologically active conjugates.About:
This article is published in Trends in Pharmacological Sciences.The article was published on 2017-04-01. It has received 735 citations till now.read more
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The current state and future directions of RNAi-based therapeutics.
TL;DR: This Review discusses key advances in the design and development of RNAi drugs leading up to this landmark achievement, the state of the current clinical pipeline and prospects for future advances, including novel RNAi pathway agents utilizing mechanisms beyond post-translational RNAi silencing.
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Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery.
TL;DR: The challenges for clinical translation of RNA-based therapeutics are discussed, with an emphasis on recent advances in biomaterials and delivery strategies, and an overview of the applications of mRNA-based delivery for protein therapy, gene editing, and vaccination are presented.
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Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields
TL;DR: This review introduces the progress of research on AMPs comprehensively and systematically, including their classification, mechanism of action, design methods, environmental factors affecting their activity, application status, prospects in various fields and problems to be solved.
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Macrocyclic Peptides as Drug Candidates: Recent Progress and Remaining Challenges
TL;DR: How macrocyclization as well as the incorporation of nonproteogenic amino acids and various conjugation strategies may be utilized to improve on these characteristics to create better drug candidates is reviewed.
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Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications
TL;DR: A comprehensive overview of the key sequences and structures utilised to provide biological and physical stability to nano-constructs, direct particles to their target and influence their cellular and tissue distribution, induce and control biological responses, and form polypeptide self-assembled nanoparticles are provided.
References
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Journal ArticleDOI
Live or let die: the cell's response to p53
Karen H. Vousden,Xin Lu +1 more
TL;DR: Understanding the complex mechanisms that regulate whether or not a cell dies in response to p53 will ultimately contribute to the development of therapeutic strategies to repair the apoptotic p53 response in cancers.
Journal ArticleDOI
Cellular uptake of the tat protein from human immunodeficiency virus
Alan D. Frankel,Carl O. Pabo +1 more
TL;DR: Experiments using radioactive protein show that tat becomes localized to the nucleus after uptake and suggest that chloroquine protects tat from proteolytic degradation, raising the possibility that, under some conditions, tat might act as a viral growth factor to stimulate viral replication in latently infected cells or alter expression of cellular genes.
Journal ArticleDOI
A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus
TL;DR: The main determinants required for Tat translocation within this sequence are delineated by synthesizing several peptides covering the Tat domain from residues 37 to 60 and the domain extending from amino acid 37 to 47, which corresponds to the α-helix structure, is not required for cellular uptake and for nuclear translocation.
Journal ArticleDOI
The third helix of the Antennapedia homeodomain translocates through biological membranes
TL;DR: It is reported here that a polypeptide of 16 amino acids in length corresponding to the third helix of the homeodomain deleted of its N-terminal glutamate is still capable of translocating through the membrane, suggesting an energy-independent mechanism of translocation not involving classical endocytosis.
Journal ArticleDOI
The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters
Paul A. Wender,Dennis J. Mitchell,Kanaka Pattabiraman,Erin T. Pelkey,Lawrence Steinman,Jonathan B. Rothbard +5 more
TL;DR: Overall, a transporter has been developed that is superior to Tat(49-57), protease resistant, and more readily and economically prepared and suggest that the guanidinium groups of Tat( 49-57) play a greater role in facilitating cellular uptake than either charge or backbone structure.
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Cellular uptake of the tat protein from human immunodeficiency virus
Alan D. Frankel,Carl O. Pabo +1 more