Cell surface receptors for extracellular matrix molecules
Citations
1,710 citations
Cites background from "Cell surface receptors for extracel..."
...It is clear that many of the interactions between cells and the ECM are mediated by the integrin family of cell surface receptors (2, 3, 13, 72)....
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1,313 citations
Cites background from "Cell surface receptors for extracel..."
...Integrins are t ~ heterodimers; each subunit has a large extracellular domain, spans the membrane once, and has a short cytoplasmic sequence (Buck and Horwitz, 1987; Hynes, 1987; Ruoslahti and Pierschbacher, 1987)....
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1,133 citations
1,104 citations
Cites background from "Cell surface receptors for extracel..."
...…multigene family of transmembrane, heterodimeric adhesion receptors mediates cell attachment to a variety of ECM molecules, including Fn, Ln, collagen types I, IV, and VI, vitronectin (Vn), fibrinogen, and thrombospondin (reviewed by Ruoslahti and Pierschbacher, 1986; Buck and Horwitz, 1987)....
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...Tyrosine phosphorylation on the /~jchain may regulate affinity for both Fn and talin (Burridge, 1986; Hirst et al., 1986; Buck and Horwitz, 1987)....
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1,041 citations
References
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