Cell viability in scoliotic discs in relation to disc deformity and nutrient levels.
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Cites background from "Cell viability in scoliotic discs i..."
...Although little information is available to relate nutrient supply to disc properties in patients, a relationship has been found between loss of cell viability and a fall in nutrient transport in scoliotic discs [80,81]....
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904 citations
Cites background from "Cell viability in scoliotic discs i..."
...Loss of nutrient supply could thus lead to cell death, as is seen in scoliotic discs, where endplate calcification(14,47) (Figure 3) appears to lead to cell death.(18,19)...
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...Loss of transport of a gaseous tracer into scoliotic discs correlated with loss of cell viability.(18,19) Thus, the association between disc degeneration and disturbances to nutrient supply are strong....
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"Cell viability in scoliotic discs i..." refers methods in this paper
...These were compared with those estimated for a completely permeable endplate using the diffusion equation; disc dimensions were obtained from radiographs, and values of diffusion coefficients from the literature.(15,42)...
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"Cell viability in scoliotic discs i..." refers background in this paper
...In scoliosis, the cell density also may be compromised because of a fall in nutrient supply.(34,42) The current study focused on cell viability changes in human intervertebral discs of patients with scoliosis to determine whether cell death differs on either side of the disc, contributing to the metabolic changes across scoliotic discs....
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